HD-MEA Probes

High-density microelectrode arrays with large sensing areas


Our high-density microelectrode array, also known as multielectrode array, (HD-MEA) probes feature 4,096 low-noise microelectrodes that allow for simultaneous electrophysiological recording.

Overview

Your partner in drug discovery

Cellular networks often require time, expertise and endeavor to obtain the performance required to validate research hypotheses. With 3Brain as your technology partner, you will be able to capture every cell signal in high resolution.

Our powerful multielectrode array (HD-MEA) probes collect high-density electrophysiological data from preparations made of brain slices, neuronal tissue, human-derived stem cells, brain organoids, retinal tissue and cardiac cultures.

The dimension, distance and spatial arrangement of the microelectrodes over large areas have been specifically designed to allow you to grasp as much detail as possible, without losing sight of the big picture in your network dynamics.

Different HD-MEA chip models for our microelectrode arrays, also known as multielectrode arrays, are available to match your experimental needs in terms of resolution, field of view and stimulation capabilities.

Designed for in vitro cell cultures

HD-MEA Prime

Prime is a high-density microelectrode array (multielectrode array) integrating 4,096 recording electrodes on a small and compact area of 2.67mm x 2.67mm, centred on a flat area of ~3mm x 3mm. This arrangement is ideal to reduce the number of seeded cells.

Each microelectrode is 21µm x 21µm, with a 42µm pitch. The internal diameter of the glass ring is 25mm, with a height of 7mm.




More space to accommodate large tissues

HD-MEA Arena

Arena has the same microelectrode recording array as the Prime model (4,096 electrodes in a 2.67mm x 2.67mm area), but offers a larger surrounding flat area (6mm x 6mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21µm x 21µm, with a 42 µm pitch. The internal diameter of the glass ring is 25mm, with a height of 7mm.



Send electrical signals to your samples

HD-MEA Stimulo

The Stimulo CMOS-MEA  features a large sensing area (5.12mm x 5.12mm) with an increased electrode pitch of 81µm. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining high spatial resolution. 

Moreover, the Stimulo model offers a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21µm x 21µm. The internal diameter of the glass ring is 25mm, with a height of 7mm.




Tech specs

HD-MEA Prime

Main Electrode Array
mode of operation recording
# of electrodes 4096 arranged in a 64 x 64 grid
electrodes' area size (active size) 2.67mm x 2.67mm
electrode size 21µm x 21µm
electrode pitch 42µm
Working Area
flat area size ~3mm x 3mm

HD-MEA Arena

Main Electrode Array
mode of operation recording
# of electrodes 4096 aranged in a 64 x 64 grid
electrodes' area size (active area) 2.67mm x 2.67mm
electrode size 21µm x 21µm
electrode pitch 42µm
Working Area
flat area size ~6mm x 6mm

HD-MEA Stimulo

Main Electrode Array
mode of operation recording
# of electrodes 4096 arranged in a 64 x 64 grid
electrodes' area (active area) 5.12mm x 5.12mm
electrode size 21µm x 21µm
electrode pitch 81µm
Second Electrode Array
mode of operation stimulation
# of electrodes 16 arranged in a 4 x 4 grid and uniformly interspersed between main array
electrodes' area 3.96mm x 3.96mm
electrode size 21µm x 21µm
electrode pitch 1.3mm
Working Area
flat area size ~6mm x 6mm