Optimized software for recording and analyzing HD electrophysiological data
BrainWave 4 pairs with 3Brain's CMOS-based high density multielectrode arrays (CMOS-MEAs) to visualize, record, and analyze electrophysiological cell activity in real-time.
Customizable display tools show this dense data in a user-friendly video interface. Pixels on the color-coded activity map correspond with the 4,096 electrodes
with changes in color representing activity spikes/voltage traces.
Sophisticated algorithms make it possible to observe spatial distribution and activity patterns and detect isolated signals.
To showcase and share results, these specially configured activity maps can be exported directly into videos.
BrainWave 4 features advanced visualization settings that further the study of organoids, animal- and human-derived stem cells, neuronal networks, brain slices, and the retina. Superimposing an image (or several) of the tissue culture onto the color-coded activity map makes it easy to locate and observe cell activity detected by the HD-MEA probe.
Thanks to the wide array of selection tools on BrainWave 4, there are an infinite number of ways to organize and analyze HD electrophysiological data.
Selected channels can also be grouped and compared with other groups, facilitating data analysis, creating graphs, and exporting files. Raw CMOS-MEA data can also be filtered by a variety of statistics such as mean firing rate, where only electrodes within a given range are included.
BrainWave 4 performs both real-time and off-line analyses on the HD electrophysiological data collected on 4,096 channels. After spike detection or local field potential (LFP) detection (available on-line and off-line) is configured and run, a myriad of calculations are possible, such as:
The new BrainWave 4 software offers a host of compression strategies to simplify data management and save space on your hard disk. Dynamic lossy compression lets you choose the percentage of relevant signal to be preserved (signal masking) and the percentage of noise to be discarded (noise blanking).
BrainWave 4 stores all your data using an HDF5 hierarchical data format (www.hdfgroup.org). This open-source, cross-platform, large data storage solution is supported by most data analysis platforms like Python, Matlab, Scilab, Octave and R. Additionally, charts and images generated from raw data can be exported as Microsoft Excel spreadsheets.
Brainwave 4 offers a series of add-ons designed to meet researchers' needs for specific experiments and data analyses.
EVOS is a complete tool to record and analyze evoked activity in brain slices in real-time and off-line. It's suited for Long Term Potentiation (LTP), Long Term Depression (LTD) and experimental protocols which involve recording evoked local field potentials in brain tissues. With this add-on, you can set up an ad-hoc stimulation protocol, record raw data in specific intervals to save hard drive space and extract signal features like peak amplitude, delay and signal energy in real-time.
|Uncompressed raw data recording||✔||✔||✔|
|Real-time spike and LFP detection||✔||✔||✔|
|Online data filtering||-||✔||✔|
|Spike and LFP data recording||-||✔||✔|
|Compressed raw data recording||-||-||✔|
|Memory buffer extension||-||-||✔|
|Off-line data filtering||✔||✔||✔|
|Spike and LFP detection on single files||✔||✔||✔|
|Average and mean firing rates||✔||✔||✔|
|Export raw data||✔||✔||✔|
|Export basic video||✔||✔||✔|
|Export full video||-||✔||✔|
|Channel grouping by statistic||-||✔||✔|
|Superimpose images on MEA layers||-||✔||✔|
|Box plot statistics||-
|Export chart data in Excel format||-||-||✔|
|Multiple file batch analysis||-||-||✔|
|License||FREE||CONTACT US||CONTACT US|
|EVOS Recorder||CONTACT US|