Brain tissues, safety and toxicology

Boost studies in neuronal circuitry and drug discovery through functional imaging of brain organoids, tissues and slices

Overview

Brain tissues

Our high-density microelectrode array, also known as a multielectrode array (HD-MEA), can visualize both spiking activity and field potential propagations (fEPSP, Population Spikes) over large neuronal networks in acute brain tissue preparations at unprecedented spatial and temporal resolutions, enabling you to:

  • Monitor spontaneous activity patterns over large brain regions.
  • Map chemically and electrically induced electrophysiological activity propagations over multiple circuits. See more
  • Apply plasticity protocols and reliably assess induced changes. See more
Fast ripples detected in the hippocampus and DG. Adapted from F. Ortiz, R. Gutiérrez, SfN 2016 (poster).  See more
Fast ripples propagating in a disorganized manner. Adapted from F. Ortiz, R. Gutiérrez, SfN 2016 (poster)  See more

Safety, toxicology and mechanism of action

Using our high-density microelectrode array, or multielectrode array (HD-MEA), researchers can study neuronal circuitry and neuronal assembly communication in label-free mode, at a micro-scale level and over large regions. See videos

This is of great interest to those seeking an understanding of the potential targets of molecules, for example in the field of epilepsy. See more


Functional images of an inter-ictal event propagating from the Dentate Gyrus to the Perirhinal Cortex. The colorful representation of the electrophysiological activity recorded by the HD-MEA has been superimposed onto the image of the slice. Adapted from Ferrea et al., Front. Neural Circuits 2012. See more

LTP on the CA1 dendritic region induced by High Frequency Stimulation (HFS) delivered to the CA3 area. Upper row: field EPSP (left) is potentiated after HFS (right). Lower row: no potentiation occurs when the slice is perfused with D-AP5. The HD-MEA's large sensing area enables studying the whole effect on the areas of interest. Courtesy of Aptuit, Verona, Italy.

Long Term Potentiation and Depression

LTP/LTD experimental protocols are routinely used in evaluating the memory deficit induced by potentially neurotoxic compounds. Our high-density microelectrode array, or multielectrode array (HD-MEA), allows superior performance in such experiments, thanks to the ability to gather high-resolution electrophysiological data with high statistical significance and to investigate heterogeneous compound effects in smaller brain regions.


See videos