Publications

Neuronal Cultures

Revealing directed effective connectivity of cortical neuronal networks from measurements

Revealing directed effective connectivity of cortical neuronal networks from measurements

(paper)

Sun C., Lin K.C., Yeung Y., Ching E.S.C., Huang Y., Lai P., and Chan C.K.

APS Physics (2022). DOI: 10.1103/PhysRevE.105.044406

Acute Retina

A novel approach to the functional classification of retinal ganglion cells

A novel approach to the functional classification of retinal ganglion cells

(paper)

Hilgen G., Kartsaki E., Kartysh V., Cessac B. and Sernagor E.

Open Biol (2022). DOI: 0.1098/rsob.210367

Organoids

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina

(paper)

Dorgau B., Georgiou M., Chaudhary A., Moya-Molina M., Collin J., Queen R., Hilgen G., Davey T., Hewitt P., Schmitt M., Kustermann S., Pognan F., Steel D. H., Sernagor E., Armstrong L., and Lako M.

Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010

Acute Brain Slices

Implementation of biohybrid olfactory bulb on a high-density CMOS-chip to reveal large-scale spatiotemporal circuit information

Implementation of biohybrid olfactory bulb on a high-density CMOS-chip to reveal large-scale spatiotemporal circuit information

(paper)

Hu X., Khanzada S., Klütsch D.,Calegari F., and Amin H.

Biosensors and Bioelectronics (2022). DOI: 10.1016/j.bios.2021.113834

Acute Brain Slices

Non-Linear Frequency Dependence of Neurovascular Coupling in the Cerebellar Cortex Implies Vasodilation–Vasoconstriction Competition

Non-Linear Frequency Dependence of Neurovascular Coupling in the Cerebellar Cortex Implies Vasodilation–Vasoconstriction Competition

(paper)

Gagliano G., Monteverdi A., Casali S., Laforenza U., Gandini Wheeler-Kingshott C.A.M., D'Angelo E., and Mapelli L.

Cells (2022). DOI: 10.3390/cells11061047

Cardiomyocyte

All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials

All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials

(paper)

Bruno G. , Melle G. , Barbaglia A. , Iachetta G., Melikov R., Perrone M., Dipalo M., and Angelis F.D.

Advanced Science (2021). DOI: 10.1002/advs.202100627

Acute Brain Slices

Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice

Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice

(paper)

Longatti A., Ponzoni L., Moretto E., Giansante G., Lattuada N., Colombo M.N., Francolini M., Sala M., Murru L. , and Passafaro M.

Mol Neurobiol. (2021). DOI: 10.1007/s12035-021-02502-x

Organoids

Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array

Human derived cortical excitatory neurospheroids showed spontaneous activity on micro electrodes array

(conf. proc.)

Muzzi L. , Falappa M., Maccione A. , Di Lisa D. , Frega M. , and Martinoia S.

IEEE (2021) DOI: 10.1109/NER49283.2021.9441261

Neuronal Cultures

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

(paper)

Cutarelli A., Martínez-Rojas V.A., Tata A., Battistella I., Rossi D., Arosio D., Musio C., and Conti L.

Cells (2021). DOI: 10.3390/cells10051127

Cardiomyocyte

Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

(paper)

Iachetta G., Colistra N., Melle G., Deleye L., Tantussi F., Angelis F.D., and Dipalo M.

Toxicology and Applied Pharmacology (2021). DOI: 10.1016/j.taap.2021.115480

Acute Brain Slices

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

(paper)

Gonzalez-Calvo I., Iyer K., Carquin M., Khayachi A., Giuliani F. A., Sigoillot S. M., Vincent J., Seveno M., Veleanu M., Tahraoui S., Albert M., Vigy O., Bosso-Lefevre C., Nadjar Y., Dumoulin A., Triller A., Bessereau J-L., Rondi-Reig L., Isope P., and Selimi F.

eLife (2021) DOI: 10.7554/eLife.65712

Acute Retina

Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

(paper)

Zerti D., Hilgen G., Dorgau B., Collin J., Ader M., Armstrong L., Sernagor E., and Lako M.

Stem Cells Journal (2021). DOI: 10.1002/stem.3365

Acute Brain Slices

Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions

Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions

(paper)

Ixmatlahua D. J., Vizcarra B., Gómez-Lira G., Romero-Maldonado I., Ortiz F., Rojas-Piloni G. and Gutiérrez R.

The Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.2590-19.2020

Organoids

Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

(paper)

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

Acute Brain Slices

A Claustrum in Reptiles and its role in Slow-Wave Sleep

A Claustrum in Reptiles and its role in Slow-Wave Sleep

(paper)

Norimoto H., Fenk L. A., Li H., Tosches M. A., Gallego-Flores T., Hain D., Reiter S., Kobayashi R., Macias A., Arends A., Klinkmann M. and Laurent G.

Nature (2020). DOI: https://doi.org/10.1038/s41586-020-1993-6

Acute Retina

Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina

Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina

(paper)

Puller C., Duda S., Lotfi E., Arzhangnia Y., Block C. T., Ahlers M. T. and Greschner M.

Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.1374-19.2019

Signal Processing

Neural field models for latent state inference: Application to large-scale neuronal recordings

Neural field models for latent state inference: Application to large-scale neuronal recordings

(paper)

Rule M. E., Schnoerr D., Hennig M. H. and Sanguinetti G.

PLOS Computational Biology (2019). DOI: https://doi.org/10.1371/journal.pcbi.1007442

Acute Retina

Investigating the Effects of Mechanical Stimulation on Retinal Ganglion Cell Spontaneous Spiking Activity

Investigating the Effects of Mechanical Stimulation on Retinal Ganglion Cell Spontaneous Spiking Activity

(paper)

Marrese M., Lonardoni D., Boi F., Hoorn H.V., Maccione A., Zordan S., Lannuzzi D. and Berdondini L.

Front. Cell. Neurosci. (2019). DOI: https://doi.org/10.3389/fnins.2019.01023

Neuronal Cultures

Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

(conf. proc.)

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Organoids

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

(paper)

Mellough C. B., Collin J., Queen R., Hilgen G., Dorgau B., Zerti D., Felemban M., White K., Sernagor E., Lako M.

Stem Cell Translational Medicine (2019), DOI: 10.1002/sctm.18-0267

Acute Retina

Non-parametric Physiological Classification of Retinal Ganglion Cells in the Mouse Retina

Non-parametric Physiological Classification of Retinal Ganglion Cells in the Mouse Retina

(paper)

Jouty J., Hilgen G., Sernagor E. and Hennig M.H.

Front. Cell. Neurosci. (2018). DOI: https://doi.org/10.3389/fncel.2018.00481

Acute Brain Slices

High Density Multi Electrode Array: a new tool to monitor seizure-like activity evoked by different convulsant drugs

High Density Multi Electrode Array: a new tool to monitor seizure-like activity evoked by different convulsant drugs

(conf. proc.)

Sessolo M., Ugolini A., Maccione A., Gandolfo M., Corsi M., Virginio C.

SFN (2018). San Diego, CA, USA.

Organoids

Development of central nervous system 3D in vitro models to study molecular mechanisms and develop therapeutic strategies for motor neuron diseases

Development of central nervous system 3D in vitro models to study molecular mechanisms and develop therapeutic strategies for motor neuron diseases

(conf. proc.)

Faravelli I., Mapelli L., Tamanini S., Cordiglieri C., Rizzuti M., Forotti G., Bresolin N., Comi G.P., Nizzardo M., Corti S.

SFN (2018). San Diego, CA, USA.

Acute Brain Slices

Early Appearance and Spread of Fast Ripples in the Hippocampus in a Model of Cortical Traumatic Brain Injury

Early Appearance and Spread of Fast Ripples in the Hippocampus in a Model of Cortical Traumatic Brain Injury

(paper)

Ortiz F., Karel Zapfe W.P., Draguhn A. and Gutiérrez R.

Journal of Neuroscience (2018). DOI: https://doi.org/10.1523/JNEUROSCI.3507-17.2018

Signal Processing

Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings

Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings

(paper)

Pastore V. P., Massobrio P., Godjoski A. and Martinoia S.

PLOS Computational Biology (2018). DOI: https://doi.org/10.1371/journal.pcbi.1006381

Cardiomyocyte

Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

(paper)

Dipalo M., Melle G., Lovato L., Jacassi A., Santoro F., Caprettini V., Schirato A., Alabastri A., Garoli D., Bruno G., Tantussi F., De Angelis F.

Nature Nanotechnology (2018). DOI: https://doi.org/10.1038/s41565-018-0222-z

Technology

Exploiting All Programmable SoCs in Neural Signal Analysis: A Closed-Loop Control for Large-Scale CMOS Multielectrode Arrays

Exploiting All Programmable SoCs in Neural Signal Analysis: A Closed-Loop Control for Large-Scale CMOS Multielectrode Arrays

(paper)

Seu G. P., Angotzi G. N., Boi F., Raffo L., Berdondini L., and Meloni P.

IEEE Transactions on Biomedical Circuits and Systems (2018). DOI: 10.1109/TBCAS.2018.2830659

Organoids

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

(paper)

Hallam D., Hilgen G., Dorgau B., Zhu L., Yu M., Bojic S., Hewitt P., Schmitt M., Uteng M., Kustermann S., Steel D., Nicholds M., Thomas R., Treumann A., Porter A., Sernagor E., Armstrong L. and Lako M.

Stem Cells (2018). DOI: https://doi.org/10.1002/stem.2883

Signal Processing

Spike Train Synchrony Analysis of Neuronal Cultures

Spike Train Synchrony Analysis of Neuronal Cultures

(conf. proc.)

Lama N., Hargreaves A., Stevens B. and McGinnity T.M.

International Joint Conference on Neural Networks (IJCNN) (2018). DOI: 10.1109/IJCNN.2018.8489728

Acute Brain Slices

Purkinje cells firing recorded by a high density multi-electrode array: a new tool for compounds validation

Purkinje cells firing recorded by a high density multi-electrode array: a new tool for compounds validation

(conf. proc.)

Ugolini A., Sessolo M., Maccione A., Bettini E., Gandolfo M., Corsi M., Virginio C.

FENS conference (2018). Berlin, Germany.

Neuronal Cultures

State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures

State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures

(paper)

Nieus T., D’Andrea V., Amin H., Di Marco S., Safaai H., Maccione A., Berdondini L. and Panzeri S.

Scientific Reports (2018). DOI: 10.1038/s41598-018-23853-x

Acute Retina

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells

(paper)

Stroh S., Puller C., Swirski S., Holzel M., van der Linde L.I.S., Segelken J., Schultz K, Block C., Monyer H., Willecke K., Weiler R., Greschner M., Janssen-Bienhold U. and Dedek K.

The Journal of Neuroscience (2018). DOI: https://doi.org/10.1523/JNEUROSCI.0141-17.2018

Technology

Fabrication of Multielectrode Arrays for Neurobiology Applications

Fabrication of Multielectrode Arrays for Neurobiology Applications

(book chapter)

Malerba M., Amin H., Angotzi G. N., Maccione A., Berdondini L.

Cell-Based Microarrays, Methods in Molecular Biology, Editors: Ertl P., Rothbauer M., Springer (2018). DOI: https://doi.org/10.1007/978-1-4939-7792-5_12

Neuronal Cultures

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics

Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics

(paper)

Amin H., Marinaro F., De Pietri Tonelli D., Berdondini L.

Scientific Report (2017). DOI: 10.1038/s41598-017-15793-9

Signal Processing

SPICODYN: A Toolbox for the Analysis of Neuronal Network Dynamics and Connectivity from Multi-Site Spike Signal Recordings

SPICODYN: A Toolbox for the Analysis of Neuronal Network Dynamics and Connectivity from Multi-Site Spike Signal Recordings

(paper)

Pastore V. P., Godjoski A., Martinoia S., Massobrio P.

Neuroinform (2017). DOI: https://doi.org/10.1007/s12021-017-9343-z

Technology

Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

(paper)

Lonardoni D., Hayder A., Di Marco S., Maccione A., Berdondini L., Nieus T.

PLOS, computation biology (2017). DOI: https://doi.org/10.1371/journal.pcbi.1005672

Neuronal Cultures

Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge

Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge

(paper)

Dante S., Petrelli A., Petrini E., Marotta E., Maccione A., Alabastri A., Quarta A., De Donato F., Ravasenga T., Sathya A., Cingolani R., Proietti Zaccaria R., Berdondini L., Barberis A., Pellegrino T.

ACS Nano (2017). DOI:10.1021/acsnano.7b00397

Acute Brain Slices

Polyethylene glycol restores axonal conduction after corpus callosum transection

Polyethylene glycol restores axonal conduction after corpus callosum transection

(paper)

Bamba R., Riley D. C., Boyer R. B., Pollins A.C., Shack R.B., Thayer W.P.

Neural regeneration research (2017). DOI: 10.4103/1673-5374.206645

Neuronal Cultures

High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies

High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies

(paper)

Amin H., Nieus T., Lonardoni D., Maccione A. and Berdondini L.

Scientific Reports (2017). DOI: 10.1038/s41598-017-02635-x

Signal Processing

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays

(paper)

Hilgen G., Sorbaro M, Pirmoradian S, Muthmann J-O., Kepiro I, Ullo S., Rmairez C. J., Encinas A. P., Maccione A., Berdondini L., Murino V., Sona D., Cella Zanacchi F., Sernagor E., Hennig M.

Cell Reports (2017). DOI: http://dx.doi.org/10.1016/j.celrep.2017.02.038

Acute Retina

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

(paper)

Hilgen G., Pirmoradian S., Pamplona D., Kornprobst P., Cessac B., Hennig M., Sernagor E.

Sci Rep. (2017). DOI: 10.1038/srep42330

Acute Brain Slices

Exploiting high content datasets recorded with high density Multi Electrode Array to investigate compounds functional effects with LTP protocols in cortico-hippocampal brain slices

Exploiting high content datasets recorded with high density Multi Electrode Array to investigate compounds functional effects with LTP protocols in cortico-hippocampal brain slices

(conf. proc.)

Zordan S., Ugolini A., Virginio C., Corsi M., Lonardoni D., Gandolfo M., Maccione A. and Berdondini L.

SFN conference (2016). San Diego, CA, USA.

Acute Retina

Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses

Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses

(paper)

Barrett J. M., Hilgen G. and Sernagor E.

Sci Rep. (2016). DOI: 10.1038/srep33565

Technology

Specific Neuron Placement on Gold and Silicon Nitride-Patterned Substrates through a Two-Step Functionalization Method

Specific Neuron Placement on Gold and Silicon Nitride-Patterned Substrates through a Two-Step Functionalization Method

(paper)

Mescola A., Canale C., Prato M., Diaspro A., Berdondini L., Maccione A., and Dante S.

Langmuir (2016). DOI: 10.1021/acs.langmuir.6b01352.

Acute Retina

Rank order coding: a retinal information decoding strategy revealed by large-scale multielectrode array retinal recordings.

Rank order coding: a retinal information decoding strategy revealed by large-scale multielectrode array retinal recordings.

(paper)

Portelli G., Barrett J.M., Hilgen G., Masquelier T., Maccione A., Di Marco S., Berdondini L., Kornprobst P., Sernagor E.

ENeuro (2016). DOI: 10.1523/ENEURO.0134-15.2016.

Signal Processing

ToolConnect: a functional connectivity toolbox for in vitro networks

ToolConnect: a functional connectivity toolbox for in vitro networks

(paper)

Pastore V. P., Poli D., Godjoski A., Martinoia S., Massobrio P.

Frontiers in Neuroinformatics (2016). DOI: 10.3389/fninf.2016.00013

Neuronal Cultures

Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for three-month culture with 4096-electrode arrays

Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for three-month culture with 4096-electrode arrays

(paper)

Amin H., Maccione A., Marinaro F., Zordan S., Nieus T., Berdondini L.

Front. Neurosci. (2016). DOI: 10.3389/fnins.2016.00121.

Neuronal Cultures

State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Bursts

State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Bursts

(paper)

Yuichiro Y., Ryohei K. and Hirokazu T.

Front. Syst. Neurosci. (2016). DOI: 10.3389/fnsys.2016.00028.

Neuronal Cultures

Propagation and synchronization of reverberatory bursts in developing cultured networks

Propagation and synchronization of reverberatory bursts in developing cultured networks

(paper)

Huang CH., Huang YT., Chen CC., Chan CK.

J Comput Neurosci (2016). DOI: 10.1007/s10827-016-0634-4.

Signal Processing

Spike detection for large neural populations using high density multielectrode arrays

Spike detection for large neural populations using high density multielectrode arrays

(paper)

Muthmann O., Amin H., Sernagor E., Maccione A., Panas D., Berdondini L., Bhalla U. S., Hennig M.

Frontiers in Neuroinformatics (2015). ISSN:1662-5196 DOI:10.3389/fninf.2015.00028

Neuronal Cultures

Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques

Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques

(conf. proc.)

Nieus T. , Di Marco S. , Maccione A. , Amin H. , Berdondini L.

Engineering in Medicine and Biology Society - 37th Annual International Conference of the IEEE (2015). DOI: 10.1109/EMBC.2015.7319211.

Neuronal Cultures

High-density MEA recordings unveil the dynamics of bursting events in Cell Cultures

High-density MEA recordings unveil the dynamics of bursting events in Cell Cultures

(conf. proc.)

Lonardoni D., Di Marco S., Amin H., Maccione A., Berdondini L., Nieus T.

Engineering in Medicine and Biology Society - 37th Annual International Conference of the IEEE (2015). DOI: 10.1109/EMBC.2015.7319212.

Technology

Microelectronics, bioinformatics and neurocomputation for massive neuronal recordings in brain circuits with large scale multielectrode array probes

Microelectronics, bioinformatics and neurocomputation for massive neuronal recordings in brain circuits with large scale multielectrode array probes

(paper)

Maccione A., Gandolfo M., Zordan S., Amin H., Di Marco S., Nieus T., Angotzi G.N., Berdondini L.

Brain Research Bulletin (2015). DOI: https://doi.org/10.1016/j.brainresbull.2015.07.008

Neuronal Cultures

Sloppiness in Spontaneously Active Neuronal Networks

Sloppiness in Spontaneously Active Neuronal Networks

(paper)

Panas D., Amin H., Maccione A., Muthmann O., van Rossum M., Berdondini L. and Hennig M.

Journal of Neuroscience (2015). DOI: 10.1523/JNEUROSCI.4421-14.2015.

Neuronal Cultures

Functional Connectivity Estimation over Large Networks at Cellular Resolution based on Electrophysiological Recordings and Structural Prior

Functional Connectivity Estimation over Large Networks at Cellular Resolution based on Electrophysiological Recordings and Structural Prior

(paper)

Ullo S. , Nieus T. , Sona D. , Maccione A. , Berdondini L. and Murino V.

Frontiers in Neuroanatomy (2014), DOI: 10.3389/fnana.2014.00137.

Signal Processing

Characterizing neural population response with high-density multielectrode arrays

Characterizing neural population response with high-density multielectrode arrays

(conf. proc.)

Pirmoradian S., Hilgen G., Muthmann O., Maccione A., Bhalla U., Berdondini L., Sernagor E., Hennig M. H.

SFN conference (2014). Washington, DC, USA.

Technology

Large-Scale recording of light-evoked responses in the retinal ganglion cell layer of the explanted retina: A new HD experimental platform

Large-Scale recording of light-evoked responses in the retinal ganglion cell layer of the explanted retina: A new HD experimental platform

(conf. proc.)

Di Marco S., Maccione A., Hilgen G., Pirmoradian S., Nieus T., Hennig M., Sernagor E., Berdondini L.

SFN November (2014). Washington, DC, USA.

Technology

Structured neuronal networks investigated by high-resolution MEAs

Structured neuronal networks investigated by high-resolution MEAs

(conf. proc.)

Simi A., Bosca A., Maccione A., Nieus T., Brandi F., Dante S. and Berdondini L.

FENS Forum (2012) Barcelona, Spain.

Acute Retina

A high-resolution experimental platform for large-scale recording of light-evoked responses in the retinal ganglion cell layer

A high-resolution experimental platform for large-scale recording of light-evoked responses in the retinal ganglion cell layer

(conf. proc.)

Di Marco S., Maccione A., Nieus T., Hennig M., Pirmoradian S., Hilgen G., Sernagor E., Berdondini L.

FENS Conference (2014). Milan, Italy.

Neuronal Cultures

Differentiation and functional integration of adult-born hippocampal neurons: a study on high-resolution microelectrode arrays (MEA)

Differentiation and functional integration of adult-born hippocampal neurons: a study on high-resolution microelectrode arrays (MEA)

(conf. proc.)

Simi A., Maccione A., Nieus T., De Pietri Tonelli D., Berdondini L.

9th FENS Meeting (2014). Milan, Italy.

Neuronal Cultures

Alzheimer's disease (AD) in-vitro model: a novel drug screening approach on 4096-microelectrode recording arrays

Alzheimer's disease (AD) in-vitro model: a novel drug screening approach on 4096-microelectrode recording arrays

(conf. proc.)

Amin H., Maccione A., Nieus T., Berdondini L.

9th FENS Meeting (2014). Milan, Italy.

Acute Retina

High Resolution Large-Scale Recordings of Light Responses from Mouse Retinal Ganglion Cells

High Resolution Large-Scale Recordings of Light Responses from Mouse Retinal Ganglion Cells

(conf. proc.)

Hilgen G., Maccione A., Di Marco S., Berdondini L., Sernagor E.

MEA meeting (2014). Reutlingen, Germany.

Acute Brain Slices

Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse

Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse

(paper)

Medrihan L., Ferrea E., Greco B., Baldelli P. and Benfenati F.

Cerebral Cortex (2014). DOI: 10.1093/cercor/bhu141

Technology

3D plasmonic hollow nanoantennas as tools for neuroscience applications

3D plasmonic hollow nanoantennas as tools for neuroscience applications

(conf. proc.)

Dipalo M., Malerba M., Messina G. C., La Rocca R., Amin H., Maccione A., Berdondini L., De Angelis F.

CLEO: Science and Innovations (2014). San Jose, CA, USA. DOI: https://doi.org/10.1364/CLEO_SI.2014.STh4H.3

Signal Processing

A computational model of hippocampal neuronal networks: the role of connectivity in the appearance of synchronized bursting events

A computational model of hippocampal neuronal networks: the role of connectivity in the appearance of synchronized bursting events

(conf. proc.)

Lonardoni D., Berdondini L., Nieus T.

EMRS spring meeting (2014). Lille, France.

Technology

3D plasmonic nanoelectrodes for intracellular recording of large-scale neuronal networks

3D plasmonic nanoelectrodes for intracellular recording of large-scale neuronal networks

(conf. proc.)

Dipalo M., Malerba M., Simi A., Amin H., Maccione A., Berdondini L., De Angelis F.

EMRS spring meeting (2014). Lille, France.

Neuronal Cultures

High resolution microelectrode arrays (MEAs) for reliably studying an in-vitro neuronal network model of induced-Alzheimer's disease

High resolution microelectrode arrays (MEAs) for reliably studying an in-vitro neuronal network model of induced-Alzheimer's disease

(conf. proc.)

Amin H., Maccione A., Nieus T., Berdondini L.

Biosensors (2014). Melbourne, Australia.

Acute Retina

Following the Ontogeny of Retinal Waves: Pan-Retinal Recordings of Population Dynamics in the Neonatal Mouse

Following the Ontogeny of Retinal Waves: Pan-Retinal Recordings of Population Dynamics in the Neonatal Mouse

(paper)

Maccione A., Hennig M., Gandolfo M., Muthmann O., van Coppenhagen J., Eglen S. J., Berdondini L. and Sernagor E.

The Journal of Physiology (2014). DOI: 10.1113/jphysiol.2013.262840.

Technology

Integration of microstructured scaffolds, neurons, and multielectrode arrays

Integration of microstructured scaffolds, neurons, and multielectrode arrays

(book chapter)

Simi A., Amin H., Maccione A., Nieus T., Berdondini L.

“Brain Extracellular Matrix in Health and Disease” Ed. Dityatev, Wehrle-Haller and Pitkänen, Elsevier 1st Edition (2014). DOI: 10.1016/B978-0-444-63486-3.00017-7

Technology

Active Pixel Sensor Multielectrode Array for High Spatiotemporal Resolution

Active Pixel Sensor Multielectrode Array for High Spatiotemporal Resolution

(book chapter)

Berdondini L., Bosca A. , Nieus T., Maccione A.

Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing (2014). DOI: https://doi.org/10.1007/978-1-4899-8038-0_7

Technology

Novel 3D plasmonic nano-electrodes for cellular investigations and neural interfaces

Novel 3D plasmonic nano-electrodes for cellular investigations and neural interfaces

(conf. proc.)

Malerba M., Dipalo M., Messina G. C., Amin H., La Rocca R., Shalabaeva V., Simi A., Maccione A., Berdondini L.

SPIE 9166, Biosensing and Nanomedicine VII (2014). DOI: 10.1117/12.2066274

Acute Retina

Mapping large scale retinal population activity with high density multielectrode arrays

Mapping large scale retinal population activity with high density multielectrode arrays

(conf. proc.)

Pirmoradian S., Hilgen G., Muthman O., Maccione A., Bhalla U., Berdondini L., Sernagor E., Hennig M.H.

Cosyne Meeting (2014). Salt Lake City, UT, USA.

Technology

Micro-/Nano-Technologies and Microelectronics for Neuroscience Research and Applications

Micro-/Nano-Technologies and Microelectronics for Neuroscience Research and Applications

(conf. proc.)

Simi A., Amin H., Maccione A., Nieus T., Di Marco S., Dipalo M., Talaei S., Koudelka-Hep M., van der Wal P. D., de Rooij N. F., Berdondini L.

6th European Conference of the International Federation for Medical and Biological Engineering IFMBE Proceedings (2015). DOI: https://doi.org/10.1007/978-3-319-11128-5_194

Technology

Brain Function: Novel Technologies Driving Novel Understanding

Brain Function: Novel Technologies Driving Novel Understanding

(book chapter)

Assad J. A. , Berdondini L. , Cancedda L. , De Angelis F. , Diaspro A. , Dipalo M. , Fellin T. , Maccione A., Panzeri S. and Sileo L.

Bioinspired Approaches for Human-Centric Technologies, Cingolani, Roberto (Ed.) (2014). DOI: 10.1007/978-3-319-04924-3

Signal Processing

Tools for analysis of high-density multielectrode recordings in the neonatal mouse retina

Tools for analysis of high-density multielectrode recordings in the neonatal mouse retina

(conf. proc.)

Hennig M., Muthmann O., Maccione A., Gandolfo M., Eglen S., Berdondini L. and Sernagor E.

Front. Neuroinform (2013). DOI: 10.3389/conf.fninf.2013.08.00004

Acute Retina

Deciphering Retinal Functional Circuitry: High Resolution Large-Scale Population Recordings From The Mouse Retinal Ganglion Cell Layer

Deciphering Retinal Functional Circuitry: High Resolution Large-Scale Population Recordings From The Mouse Retinal Ganglion Cell Layer

(conf. proc.)

Sernagor E., Hilgen G., Barrett J., Hennig M., Maccione A., Berdondini L.

European Retina Meeting ERM (2013). Alicante, Spain.

Acute Brain Slices

Can a pro-seizures effect be predicted? Evaluation of two technological approaches in hippocampal slices

Can a pro-seizures effect be predicted? Evaluation of two technological approaches in hippocampal slices

(conf. proc.)

Ugolini A., Maccione A., Gandolfo M., Corsi M., Virginio C.

Safety Pharmacology Society Meeting (2013). Rotterdam, The Netherlands.

Acute Brain Slices

Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

(paper)

Toader O., Forte N., Orlando M., Ferrea E., Raimondi A., Baldelli P., Benfenati F. and Medrihan L.

Front Cell Neurosci. (2013). DOI: 10.3389/fncel.2013.00138.

Neuronal Cultures

Investigating the interplay between intrinsic and evoked activities in cultured neuronal networks by dimensional reduction techniques and high-density MEAs

Investigating the interplay between intrinsic and evoked activities in cultured neuronal networks by dimensional reduction techniques and high-density MEAs

(conf. proc.)

Nieus T., Maccione A. and Berdondini L.

CNS Meeting 2013 - BMC Neuroscience (2013). DOI: 10.1186/1471-2202-14-S1-P24.

Signal Processing

Estimating the fraction of falsely detected spikes in high density microelectrode array recordings based on correlations

Estimating the fraction of falsely detected spikes in high density microelectrode array recordings based on correlations

(conf. proc.)

Muthmann J-O., Amin H., Maccione A., Sernagor E., Berdondini L., Hennig M. and Bhalla U.S.

CNS Meeting - BMC Neuroscience (2013). Paris, France. DOI: https://doi.org/10.1186/1471-2202-14-S1-P25

Signal Processing

Homeostasis in large networks of neurons through the Ising model - do higher order interactions matter?

Homeostasis in large networks of neurons through the Ising model - do higher order interactions matter?

(conf. proc.)

Panas D., Maccione A., Berdondini L. & Hennig M.

CNS Meeting - BMC Neuroscience (2013). Paris, France. DOI: https://doi.org/10.1186/1471-2202-14-S1-P166

Neuronal Cultures

Neuronal network structural connectivity estimation by probabilistic features and graph heat kernels

Neuronal network structural connectivity estimation by probabilistic features and graph heat kernels

(conf. proc.)

Ullo S., Castellani U., Sona D., Del Bue A., Maccione A., Berdondini L., Murino V.

International Symposium on BIOMEDICAL IMAGING: From Nano to Macro (2013). San Francisco, CA, USA.

Technology

Electrical Coupling of Mammalian Neurons to Microelectrodes with 3D Nanoprotrusions

Electrical Coupling of Mammalian Neurons to Microelectrodes with 3D Nanoprotrusions

(paper)

Sileo L., Pisanello F., Quarta L., Maccione A., Simi A., Berdondini L., De Vittorio M., Martiradonna L.

Microelectronic Engineering (2013). DOI: https://doi.org/10.1016/j.mee.2013.03.152

Technology

Sensing and actuating electrophysiological activity on brain tissue and neuronal cultures with a high-density CMOS-MEA

Sensing and actuating electrophysiological activity on brain tissue and neuronal cultures with a high-density CMOS-MEA

(conf. proc.)

Maccione A., Simi A., Nieus T., Gandolfo M., Imfeld K., Ferrea E., Sernagor E., and Berdondini L.

IEEE conference (2013). Barcelona, Spain. DOI: 10.1109/Transducers.2013.6626875.

Acute Brain Slices

Large-scale, high resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

Large-scale, high resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

(paper)

Ferrea E., Maccione A., Medrihan L., Nieus T., Ghezzi D., Baldelli P., Benfenati F. and Berdondini L.

Front Neural Circuits (2012). DOI: 10.3389/fncir.2012.00080

Signal Processing

Estimating Electrical Conductivity Tensors of Biological Tissues Using Microelectrode Arrays

Estimating Electrical Conductivity Tensors of Biological Tissues Using Microelectrode Arrays

(paper)

Gilboa E., La Rosa P.S. & Nehorai A.

Ann Biomed Eng (2012). DOI: 10.1007/s10439-012-0581-9

Neuronal Cultures

Multi-site electrical stimulation integrated on 4096 high density micro electrode arrays (MEAs) reveals the effective connectivity of dissociated neuronal cultures

Multi-site electrical stimulation integrated on 4096 high density micro electrode arrays (MEAs) reveals the effective connectivity of dissociated neuronal cultures

(conf. proc.)

Maccione A., Nieus T., Simi A., Amin H. and Berdondini L.

SFN Conference (2012). New Orleans, LA, USA.

Signal Processing

A joint structural and functional analysis of in-vitro neuronal networks

A joint structural and functional analysis of in-vitro neuronal networks

(conf. proc.)

Ullo S., Del Bue A., Maccione A., Berdondini L. & Murino V.

International Conference on Image Processing (2012). DOI: 10.1109/ICIP.2012.6467098

Signal Processing

Towards tracking homeostatic changes on high-density multielectrode arrays

Towards tracking homeostatic changes on high-density multielectrode arrays

(conf. proc.)

Panas D., Maccione A., Berdondini L. & Hennig M.

Bernstein Conference (2012). Munich, Germany.

Technology

Beam induced deposition of 3D electrodes to improve coupling to cells

Beam induced deposition of 3D electrodes to improve coupling to cells

(paper)

Martiradonna L., Quarta L., Sileo L., Schertel A., Maccione A., Simi A., Dante A., Scarpellini A., Berdondini L. and De Vittorio M.

Microelectronic Engineering (2012). DOI: 10.1016/j.mee.2012.03.027.

Neuronal Cultures

Structural and functional identification of sub-networks in dissociated neuronal cultures: an automated multimodal analysis combining high density MEA and fluorescence imaging

Structural and functional identification of sub-networks in dissociated neuronal cultures: an automated multimodal analysis combining high density MEA and fluorescence imaging

(conf. proc.)

Maccione A., Ullo S., Simi A., Nieus T., Sona D., Del Bue A., Murino V. and Berdondini L.

MEA meeting (2012), Reutlingen, Germany.

Neuronal Cultures

Multiscale functional connectivity estimation on low density neuronal cultures recorded by high density CMOS Micro Electrode Arrays

Multiscale functional connectivity estimation on low density neuronal cultures recorded by high density CMOS Micro Electrode Arrays

(paper)

Maccione A., Garofalo M., Nieus T., Tedesco M., Berdondini L. and Martinoia S.

Journal of Neuroscience Methods (2012). DOI: 10.1016/j.jneumeth.2012.04.002.

Acute Brain Slices

Electrophysiological imaging of epileptic brain slices reveals pharmacologically confined functional changes

Electrophysiological imaging of epileptic brain slices reveals pharmacologically confined functional changes

(conf. proc.)

Ferrea E., Medrihan L., Ghezzi D., Nieus T., Baldelli P., Benfenati F. and Maccione A.

MEA meeting (2012). Reutlingen, Germany.

Technology

Investigating 2D/3D patterned networks coupled with high-resolution MEAs for functional studies

Investigating 2D/3D patterned networks coupled with high-resolution MEAs for functional studies

(conf. proc.)

Hennig M. H., Maccione A., Gandolfo M., Down M., Eglen S. J., Berdondini L. and Sernagor E.

BMC Neuroscience (2011). DOI: https://doi.org/10.1186/1471-2202-12-S1-P296

Acute Retina

Analysis of simultaneous multielectrode recordings with 4096 channels: changing dynamics of spontaneous activity in the developing retina

Analysis of simultaneous multielectrode recordings with 4096 channels: changing dynamics of spontaneous activity in the developing retina

(conf. proc.)

Hennig M., Maccione A., Gandolfo M., Down M., Eglen S. J., Berdondini L. and Sernagor E.

CNS meeting (2011). Stockholm, Sweden.

Technology

Coupling neuronal cultures grown on flexible laser-etched porous membranes with CMOS-MEA

Coupling neuronal cultures grown on flexible laser-etched porous membranes with CMOS-MEA

(conf. proc.)

Marconi E., Maccione A., Simi A., Bosca A., Brandi F., Benfenati F., Dante S. and Berdondini L.

The 6th International Conference on Microtechnologies in Medicine and Biology (2011). Lucerne, Switzerland.

Signal Processing

What can MaxEnt reveal about high-density recordings and what can high-density recordings reveal about MaxEnt?

What can MaxEnt reveal about high-density recordings and what can high-density recordings reveal about MaxEnt?

(conf. proc.)

Dagmara P., Maccione A., Berdondini L., & Hennig M.

CNS meeting (2011). Stockholm, Sweden.

Neuronal Cultures

A comparison between low- and high-density analyses on 2D neuronal networks by means of high resolution CMOS-MEAs

A comparison between low- and high-density analyses on 2D neuronal networks by means of high resolution CMOS-MEAs

(conf. proc.)

Maccione A., Gandolfo M., Tedesco M., Imfeld K., Martinoia S., and Berdondini L.

SfN Conference (2010) San Diego, CA, USA.

Acute Brain Slices

Investigation of the spatio-temporal propagation pattern of epileptic events in cortico-hippocampal slices by means of high-density CMOS micro electrode arrays.

Investigation of the spatio-temporal propagation pattern of epileptic events in cortico-hippocampal slices by means of high-density CMOS micro electrode arrays.

(conf. proc.)

Ferrea E., Medrihan L., Maccione A., Baldelli P., Benfenati F., and Berdondini L.

SfN Conference (2010). San Diego, CA, USA.

Acute Retina

Changing dynamics of spontaneous waves during retinal development: a novel panretinal perspective achieved with the active pixel sensor (APS) 4096 electrodes array

Changing dynamics of spontaneous waves during retinal development: a novel panretinal perspective achieved with the active pixel sensor (APS) 4096 electrodes array

(conf. proc.)

Sernagor E., Maccione A., Hennig M., Gandolfo M., Eglen S., and Berdondini L.

SFN (2010). San Diego, CA, USA.