Explore new dimensions in brainresearch
Scaffold/matrix-based 3D cultures
In vitro Brain Organoids or Spheroids reproduce key brain in-vivo organization features as cell-cell 3-dimensional interactions or tissue-specific architecture. Therefore, such models are a great resource for assessing the efficacy of drugs in brain disease studies and for toxicological and compound screening. 3Brain’s single-well HD-MEAs and CorePlate™ multiwell can measure the functional activity from brain organoids at a high spatial resolution never provided before.
Advantages of 3Brain technology with brain organoids are:
Label-free functional monitoring of whole organoids with single cell spiking activity resolution
Improved statistical significance measuring from thousands of neurons simultaneously
Multiple sample recordings: 3Brain’s HD-MEAs have a sensing area of up to 25mm², allowing to record multiple spheroids in a single experiment.
Click here to know how the technology works
Integrated spike and field detection algorithms
BrainWave software detects, extracts and classifies spikes or field potentials from organoids
Superimpose and Focus
BrainWave integrates advanced tools to superimpose images of your samples on the activity map and to zoom on it. This feature allows to record selected region of interests or to focus on a specific area of activity for advanced analysis
Automated statistical analysis of network parameters
The all-in-one BrainWave software assists the user to quickly obtain results from their experimental session in a simple and intuitive way
Feel free to get in contact with us regarding demos or further detailsContact Us
A collection of reviews from our customers
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
Prof. Kim SangSeongHanyang University College of Pharmacy
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
Dr. Ryley ParrishXenon Pharmaceuticals Inc.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
Location to specific products and samples within 3Brain's resources
Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860
Stem Cell Translational Medicine (2019), DOI: 10.1002/sctm.18-0267
SFN (2018). San Diego, CA, USA.