Explore new dimensions in brain research
Scaffold/matrix-based 3D cultures
In vitro Brain Organoids or Spheroids reproduce key brain in-vivo organization features as cell–cell 3-dimensional interactions or tissue-specific architecture. This makes models a great resource for assessing the efficacy of drugs in brain disease studies and for toxicological and compound screening. 3Brain’s single-well HD-MEAs and CorePlate™ multiwell can measure functional activity from brain organoids at an unprecedented high spatial resolution.
Advantages of 3Brain technology with brain organoids are:
Label-free functional monitoring of whole organoids with single-cell spiking activity resolution.
Improved statistical significance measuring from thousands of neurons simultaneously
Multiple sample recordings: 3Brain’s HD-MEAs have a sensing area of up to 25mm², allowing to record multiple spheroids in a single experiment.
Click here to know how the technology works
Integrated spike and field detection algorithms
BrainWave software detects, extracts and classifies spikes or field potentials from organoids.
Superimpose and Focus
BrainWave integrates advanced tools to superimpose images of your samples on the activity map and zoom on it. This feature allows you to record the selected region of interestor to focus on a specific area of activity for advanced analysis.
Automated statistical analysis of network parameters
The all-in-one BrainWave softwarehelps the user to quickly obtain results from an experimental session in asimple and intuitive way.
Feel free to get in contact with our neuroscientists team for detailsContact Us
A collection of reviews from our customers
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
Prof. Kim SangSeongHanyang University College of Pharmacy
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
Dr. Ryley ParrishXenon Pharmaceuticals Inc.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
Location to specific products and samples within 3Brain's resources
Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010
IEEE (2021) DOI: 10.1109/NER49283.2021.9441261
Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860