Brain Organoids and 3D Neuronal Cultures

Explore new dimensions in brainresearch

Models

  • Brain/CorticalOrganoids

  • Retinal Organoids

  • Spheroids

  • Scaffold/matrix-based 3D cultures

Advantages

In vitro Brain Organoids or Spheroids reproduce key brain in-vivo organization features as cell-cell 3-dimensional interactions or tissue-specific architecture. Therefore, such models are a great resource for assessing the efficacy of drugs in brain disease studies and for toxicological and compound screening. 3Brain’s single-well HD-MEAs and CorePlate™ multiwell can measure the functional activity from brain organoids at a high spatial resolution never provided before.

Advantages of 3Brain technology with brain organoids are:

  • Label-free functional monitoring of whole organoids with single cell spiking activity resolution

  • Improved statistical significance measuring from thousands of neurons simultaneously

  • Multiple sample recordings: 3Brain’s HD-MEAs have a sensing area of up to 25mm², allowing to record multiple spheroids in a single experiment.

Click here to know how the technology works

Tools & Features

  • Integrated spike and field detection algorithms

    BrainWave software detects, extracts and classifies spikes or field potentials from organoids

  • Superimpose and Focus

    BrainWave integrates advanced tools to superimpose images of your samples on the activity map and to zoom on it. This feature allows to record selected region of interests or to focus on a specific area of activity for advanced analysis

  • Automated statistical analysis of network parameters

    The all-in-one BrainWave software assists the user to quickly obtain results from their experimental session in a simple and intuitive way

  • Design your experimental session

    BrainWave  intuitive graphical user interface  provides the user full control on the experimental design to rapidly obtain results from the experimental session

Feel free to get in contact with us regarding demos or further details

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Customer experience

A collection of reviews from our customers

The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.
It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Fred Jordan

FinalSpark
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Selected Publications

View all  
Organoids
Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

(selected papers)

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

Organoids
Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

(selected papers)

Mellough C. B., Collin J., Queen R., Hilgen G., Dorgau B., Zerti D., Felemban M., White K., Sernagor E., Lako M.

Stem Cell Translational Medicine (2019), DOI: 10.1002/sctm.18-0267

Organoids
Development of central nervous system 3D in vitro models to study molecular mechanisms and develop therapeutic strategies for motor neuron diseases

(conf. proc.)

Faravelli I., Mapelli L., Tamanini S., Cordiglieri C., Rizzuti M., Forotti G., Bresolin N., Comi G.P., Nizzardo M., Corti S.

SFN (2018). San Diego, CA, USA.

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