Brain Organoids and 3D Neuronal Cultures

Explore new dimensions in brainresearch

Models

Brain/CorticalOrganoids
Retinal Organoids
Spheroids
Scaffold/matrix-based 3D cultures

Advantages

In vitro Brain Organoids or Spheroids reproduce key brain in-vivo organization features as cell-cell 3-dimensional interactions or tissue-specific architecture. Therefore, such models are a great resource for assessing the efficacy of drugs in brain disease studies and for toxicological and compound screening. 3Brain’s single-well HD-MEAs and CorePlate™ multiwell can measure the functional activity from brain organoids at a high spatial resolution never provided before.

Advantages of 3Brain technology with brain organoids are:

Label-free functional monitoring of whole organoids with single cell spiking activity resolution
Improved statistical significance measuring from thousands of neurons simultaneously
Multiple sample recordings: 3Brain’s HD-MEAs have a sensing area of up to 25mm², allowing to record multiple spheroids in a single experiment.

Click here to know how the technology works

Tools & Features

Integrated spike and field detection algorithms
BrainWave software detects, extracts and classifies spikes or field potentials from organoids

Superimpose and Focus
BrainWave integrates advanced tools to superimpose images of your samples on the activity map and to zoom on it. This feature allows to record selected region of interests or to focus on a specific area of activity for advanced analysis

Automated statistical analysis of network parameters
The all-in-one BrainWave software assists the user to quickly obtain results from their experimental session in a simple and intuitive way

Design your experimental session
BrainWave intuitive graphical user interface provides the user full control on the experimental design to rapidly obtain results from the experimental session

Feel free to get in contact with us regarding demos or further details

Customer experience

A collection of reviews from our customers

The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Institute for Genomic Medicine Link to Author’s Publication

It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Fred Jordan

FinalSpark

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.

Matthias H Hennig

Computational Neuroscience and Neuroinformatics Link to Author’s Publication

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Prof. Egidio D’Angelo

University of Pavia Link to Author’s Publication

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.

Prof. Evelyne Sernagor

Retinal Neuroscience Link to Author’s Publication

We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.

Dr. Hayder Amin

Plasticity Models for Aging and Neurodegeneration (DZNE Dresden)Link to Author’s Publication

I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Prof. Kim SangSeong

Hanyang University College of Pharmacy

3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.

Dr. Ryley Parrish

Xenon Pharmaceuticals Inc.

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Michele Dipalo, PhD

Plasmon Nanotechnologies group at the Italian Institute of Technology (IIT)Link to Author’s Publication