In-Plate Intelligence

Bringing you CorePlate™: the next-generation microelectrode array system for drug discovery and neuronal networks research

A cell-electronic interface for deep access of organoids and tissues

First-in-class 3D-CMOS chip for biomarker discovery, phenotypic screening and cellular assays.

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3Brain Massimo Grattarola Award 2022
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The 3Brain - Massimo Grattarola Award applications has ended for 2022!

Thank you all for taking your time in applying for this year's Award. As we progress through the first round of evaluations, we will inform all 5 finalists at the beginning of September.

Follow us on Twitter or Linkedin, as we wait to see who will advance before the jury of this year!

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Submit your email now to recieve a reminder ahead of time for the next award:

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HyperCAM Alpha

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HyperCAM Alpha

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CorePlate™ Multiwells

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CorePlate™ Multiwells

CorePlate™ Multiwells

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HyperCAM Alpha

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HyperCAM Alpha

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CorePlate™ Multiwells

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CorePlate™ Multiwells

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Multiwell
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Single-Well
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Software
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Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well, CorePlate™-powered multi-well platform delivering high-resolution functional screening.

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3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

CorePlate™ processing capabilities convert multi-well plates into smart objects.

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The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platformfor 2D and 3D in vitro electrophysiology.

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Our genuine HD-MEA (microelectrode array) platform with everything you need for in vitro neuronal physiology. - BioCAM X

BioCAM X

Our genuine HD-MEA platform with everything you need for in vitro neuronal network physiology.

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3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs with the single-well devices.

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BrainWave 5 - Software

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multi-wells.

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BrainWave 4 - Software

BrainWave 4

The companion for our single-well HD-MEAs to visualize, record and analyze neural cell activity in real time.

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IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of single-well BioCAM systems.

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Created with Sketch.
Multi-Well
Created with Sketch.
Single-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more
3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more
The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more
Our genuine HD-MEA (microelectrode array) platform with everything you need for in vitro neuronal physiology. - BioCAM X

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more
3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more
BrainWave 5 - Software

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multiwells.

Discover more
BrainWave 4 - Software

BrainWave 4

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Created with Sketch.
Multi-Well
Created with Sketch.
Single-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more
3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more
The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more
BioCAM X - 3Brain

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more
3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more
BrainWave 5

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multiwells.

Discover more
BrainWave 4 - 3Brain

BrainWave 4

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Our Mission

3Brain strives to provide researchers with breakthrough technology to improve understanding of organs and related illnesses.

3Brain strives to provide researchers with breakthrough technology to improve the understanding of organs and their related illnesses.

How can 3Brain products boost your data?

From the bench to the paper

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Simplifying experimental setups into an all-in-one compact design with the help of advanced, user-friendly acquisition and analysis software.

1

Simplifying experimental setups into an all-in-one compact design, including an advanced and user friendly acquisition and analysis software

See the BioCAM DupleX

2

Gaining a deeper understanding of neuronal networks using a sensitive technology that provides superior spatial and temporal resolution.

2

Getting a deeper understanding of neuronal networks using a sensitive technology providing a superior spatial and temporal resolution

See CorePlate™ technology

3

Obtaining clearer and more reliable statistics while requiring fewer experiments – all in a time-efficient manner.

3

Obtaining clearer and more reliable statistics while requiring less experiments - all in a time efficient manner

See latest publications

Resources

See our MEA neuro-imaging technology in action

Explore the capabilities of our neuron processors (also known as high density microelectrode arrays - HD-MEAs) and our software tools: take a look at these experimental data samples and download the free version of BrainWave.

Latest News

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April 20, 2022

New Publication: "Revealing directed effective connectivity of cortical neuronal networks from measurements"

Can scientists model in vitro neuronal culture as a stochastic dynamical system using spatio-temporal data from HD-MEA?

Tour de force to reconstruct network connectivity & dynamics of synapses by Sun C. et. al., from the Chinese University of Hong Kong, Shatin.

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April 29, 2022

New Publication: "Receptivefield estimation in large visual neuron assemblies using a super-resolution approach"

Fascinating new method paper from Pamplona et al., using super-resolution principles and our CMOS-MEA to map the receptive fields of mouse retina from large heterogeneous neuronal populations with high fidelity.

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May 19, 2022

New Publication: "Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia"

How does drug abuse impact neural network remodeling during development?

Interesting paper from Veleanu et al. from (CNRS - Centre national de la recherche scientifique) using our CMOS-MEA to show neonatal PCP impacts connectivity, but causes no long-term difference in activity nor cytoarchitecture.

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What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

Latest Publication

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Neuronal Cultures
Functional connectivity in in vitro neuronal assemblies

Polo D., Pastore V.P., and Massobrio P.

Frontiers (2015). DOI: 10.3389/fncir.2015.00057

Acute Brain Slices
Hypoxia induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

Lobo M.E.D.V., Weir N., Hardowar L., Al Ojaimi Y., Madden R., Gibson A., Bestall S.M., Hirashima M., Schaffer C.B., Donaldson L.F., Bates D.O. and Hulse R.H.

PAIN(2022). DOI: 10.1097/j.pain.0000000000002627

Acute Retina
Receptive field estimation in large visual neuron assemblies using a super-resolution approach

Pamplona D., Hilgen G., Hennig M.H., Cessac B., Sernagor E., and Kornprobst P.

Journal of Neurophysiology (2022). DOI: 10.1152/jn.00076.2021

Organoids
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Dorgau B., Georgiou M., Chaudhary A., Moya-Molina M., Collin J., Queen R., Hilgen G., Davey T., Hewitt P., Schmitt M., Kustermann S., Pognan F., Steel D. H., Sernagor E., Armstrong L., and Lako M.

Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010

Latest Publications

View all  
Neuronal Cultures
Functional connectivity in in vitro neuronal assemblies

Polo D., Pastore V.P., and Massobrio P.

Frontiers (2015). DOI: 10.3389/fncir.2015.00057

Acute Brain Slices
Hypoxia induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

Lobo M.E.D.V., Weir N., Hardowar L., Al Ojaimi Y., Madden R., Gibson A., Bestall S.M., Hirashima M., Schaffer C.B., Donaldson L.F., Bates D.O. and Hulse R.H.

PAIN(2022). DOI: 10.1097/j.pain.0000000000002627

Acute Retina
Receptive field estimation in large visual neuron assemblies using a super-resolution approach

Pamplona D., Hilgen G., Hennig M.H., Cessac B., Sernagor E., and Kornprobst P.

Journal of Neurophysiology (2022). DOI: 10.1152/jn.00076.2021

Organoids
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Dorgau B., Georgiou M., Chaudhary A., Moya-Molina M., Collin J., Queen R., Hilgen G., Davey T., Hewitt P., Schmitt M., Kustermann S., Pognan F., Steel D. H., Sernagor E., Armstrong L., and Lako M.

Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010

Neuronal Cultures

Sun C., Lin K.C., Yeung Y., Ching E.S.C., Huang Y., Lai P., and Chan C.K.

APS Physics (2022). DOI: 10.1103/PhysRevE.105.044406

Acute Brain Slices

Mahadevan A., Codadu N.K. and Parrish R.R.

Frontiers in Neuroscience (2022). DOI: 10.3389/fnins.2022.904931

Acute Retina

Pamplona D., Hilgen G., Hennig M.H., Cessac B., Sernagor E., and Kornprobst P.

Journal of Neurophysiology (2022). DOI: 10.1152/jn.00076.2021

Organoids

Dorgau B., Georgiou M., Chaudhary A., Moya-Molina M., Collin J., Queen R., Hilgen G., Davey T., Hewitt P., Schmitt M., Kustermann S., Pognan F., Steel D. H., Sernagor E., Armstrong L., and Lako M.

Stem Cells Transl Med. (2022). DOI: 10.1093/stcltm/szab010

Do you want to know more?
Book a chat or email us, as our neuroscientist team is here to assist you.
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