In-Plate Intelligence

Bringing you CorePlate™: the next-generation microelectrode array system for drug discovery and neuronal networks research

A cell-electronic interface for deep access of organoids and tissues

First-in-class 3D-CMOS chip for biomarker discovery, phenotypic screening and cellular assays.

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3Brain Massimo Grattarola Award 2022
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The 3Brain - Massimo Grattarola Award applications has ended for 2022!

Thank you all for taking your time in applying for this year's Award. As we progress through the first round of evaluations, we will inform all 5 finalists at the beginning of September.

Follow us on Twitter or Linkedin, as we wait to see who will advance before the jury of this year!

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Submit your email now to recieve a reminder ahead of time for the next award:

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Email reminders will be sent out soon!
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HyperCAM Alpha

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HyperCAM Alpha

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CorePlate™ Multiwells

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CorePlate™ Multiwells

CorePlate™ Multiwells

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HyperCAM Alpha

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HyperCAM Alpha

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CorePlate™ Multiwells

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CorePlate™ Multiwells

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Multiwell
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Single-Well
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Software
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Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well, CorePlate™-powered multi-well platform delivering high-resolution functional screening.

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3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

CorePlate™ processing capabilities convert multi-well plates into smart objects.

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The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platformfor 2D and 3D in vitro electrophysiology.

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Our genuine HD-MEA (microelectrode array) platform with everything you need for in vitro neuronal physiology. - BioCAM X

BioCAM X

Our genuine HD-MEA platform with everything you need for in vitro neuronal network physiology.

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3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs with the single-well devices.

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BrainWave 5 - Software

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multi-wells.

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BrainWave 4 - Software

BrainWave 4

The companion for our single-well HD-MEAs to visualize, record and analyze neural cell activity in real time.

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IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of single-well BioCAM systems.

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Created with Sketch.
Multi-Well
Created with Sketch.
Single-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more
3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more
The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more
Our genuine HD-MEA (microelectrode array) platform with everything you need for in vitro neuronal physiology. - BioCAM X

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more
3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more
BrainWave 5 - Software

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multiwells.

Discover more
BrainWave 4 - Software

BrainWave 4

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Created with Sketch.
Multi-Well
Created with Sketch.
Single-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
3Brain's HyperCAM Alpha

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more
3Brain's CorePlate™ Multiwells

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more
The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more
BioCAM X - 3Brain

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more
3Brain's Single-Well HD-MEAs

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more
BrainWave 5

BrainWave 5

The software that combines all you need to acquire, analyze and manage data from CorePlate™ multiwells.

Discover more
BrainWave 4 - 3Brain

BrainWave 4

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Our Mission

3Brain strives to provide researchers with breakthrough technology to improve understanding of organs and related illnesses.

3Brain strives to provide researchers with breakthrough technology to improve the understanding of organs and their related illnesses.

How can 3Brain products boost your data?

From the bench to the paper

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Simplifying experimental setups into an all-in-one compact design with the help of advanced, user-friendly acquisition and analysis software.

1

Simplifying experimental setups into an all-in-one compact design, including an advanced and user friendly acquisition and analysis software

See the BioCAM DupleX

2

Gaining a deeper understanding of neuronal networks using a sensitive technology that provides superior spatial and temporal resolution.

2

Getting a deeper understanding of neuronal networks using a sensitive technology providing a superior spatial and temporal resolution

See CorePlate™ technology

3

Obtaining clearer and more reliable statistics while requiring fewer experiments – all in a time-efficient manner.

3

Obtaining clearer and more reliable statistics while requiring less experiments - all in a time efficient manner

See latest publications

Resources

See our MEA neuro-imaging technology in action

Explore the capabilities of our neuron processors (also known as high density microelectrode arrays - HD-MEAs) and our software tools: take a look at these experimental data samples and download the free version of BrainWave.

Latest News

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January 26, 2023

3Brain @ Conference on Advancements in Organoid Sciences

Brain organoids hold so much promise for the future of pre-clinical research & drug discovery, but how can we access their complexity?

Visit our poster at CAOS (MSH Medical School Hamburg): functional & network activity in 5-month-old brain organoids with our 3D biointerface technology!

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January 25, 2023

PIN - Research Pulse:

How does the environment shape neuronal information processing in the retina? And what does the time of the day have to do with it?

Apparently, quite a lot. For morning birds and night owls alike. Read more in this month's blog post!

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December 21, 2022

PIN - Research Pulse: Pressure point: Neuron

A new research pulse blog is out!

This month, we look at mechanobiology, and how the physical properties of the brain impact neuronal activity.

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What’s a Rich Text element?

The rich text element allows you to create and format headings, paragraphs, blockquotes, images, and video all in one place instead of having to add and format them individually. Just double-click and easily create content.

Static and dynamic content editing

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

Latest Publication

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Neuronal Cultures
Functional connectivity in in vitro neuronal assemblies

Polo D., Pastore V.P., and Massobrio P.

Frontiers (2015). DOI: 10.3389/fncir.2015.00057

Acute Brain Slices
Hypoxia induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

Lobo M.E.D.V., Weir N., Hardowar L., Al Ojaimi Y., Madden R., Gibson A., Bestall S.M., Hirashima M., Schaffer C.B., Donaldson L.F., Bates D.O. and Hulse R.H.

PAIN(2022). DOI: 10.1097/j.pain.0000000000002627

Acute Retina
Glial Bmal1 role in mammalian retina daily changes

Riccitelli S., Boi F., Lonardoni D., Giantomasi L., Barca-Mayo O., De Pietri Tonelli D., Bisti S., Di Marco S. and Berdondini L.

Scientific Reports (2022). DOI: 10.1038/s41598-022-25783-1

Organoids
Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Chichagova V., Georgiou M., Carter M., Dorgau B., Hilgen G., Collin J., Queen R., Chung G., Ajeian J., Moya-Molina M., Kustermann S., Pognan F., Hewitt P., Schmitt M., Sernagor E., Armstrong L. and Lako M.

Journal of Cellcular and Molecular Medicine (2023). DOI: 10.1111/jcmm.17670

Latest Publications

View all  
Neuronal Cultures
Functional connectivity in in vitro neuronal assemblies

Polo D., Pastore V.P., and Massobrio P.

Frontiers (2015). DOI: 10.3389/fncir.2015.00057

Acute Brain Slices
Hypoxia induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

Lobo M.E.D.V., Weir N., Hardowar L., Al Ojaimi Y., Madden R., Gibson A., Bestall S.M., Hirashima M., Schaffer C.B., Donaldson L.F., Bates D.O. and Hulse R.H.

PAIN(2022). DOI: 10.1097/j.pain.0000000000002627

Acute Retina
Glial Bmal1 role in mammalian retina daily changes

Riccitelli S., Boi F., Lonardoni D., Giantomasi L., Barca-Mayo O., De Pietri Tonelli D., Bisti S., Di Marco S. and Berdondini L.

Scientific Reports (2022). DOI: 10.1038/s41598-022-25783-1

Organoids
Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids

Chichagova V., Georgiou M., Carter M., Dorgau B., Hilgen G., Collin J., Queen R., Chung G., Ajeian J., Moya-Molina M., Kustermann S., Pognan F., Hewitt P., Schmitt M., Sernagor E., Armstrong L. and Lako M.

Journal of Cellcular and Molecular Medicine (2023). DOI: 10.1111/jcmm.17670

Neuronal Cultures

Sun C., Lin K.C., Yeung Y., Ching E.S.C., Huang Y., Lai P., and Chan C.K.

APS Physics (2022). DOI: 10.1103/PhysRevE.105.044406

Acute Brain Slices

Mahadevan A., Codadu N.K. and Parrish R.R.

Frontiers in Neuroscience (2022). DOI: 10.3389/fnins.2022.904931

Acute Retina

Riccitelli S., Boi F., Lonardoni D., Giantomasi L., Barca-Mayo O., De Pietri Tonelli D., Bisti S., Di Marco S. and Berdondini L.

Scientific Reports (2022). DOI: 10.1038/s41598-022-25783-1

Organoids

Chichagova V., Georgiou M., Carter M., Dorgau B., Hilgen G., Collin J., Queen R., Chung G., Ajeian J., Moya-Molina M., Kustermann S., Pognan F., Hewitt P., Schmitt M., Sernagor E., Armstrong L. and Lako M.

Journal of Cellcular and Molecular Medicine (2023). DOI: 10.1111/jcmm.17670

Do you want to know more?
Book a chat or email us, as our neuroscientist team is here to assist you.
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