Interfacing Neuronal Networks

Exploring the newest generation of HD-Microelectrode arrays: the CorePlate™

The 3Brain Massimo Grattarola Award
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Thank you to all applicants who applied for this year's 3Brain Massimo Grattarola Award!

Don't forget to follow us on Twitter or Linkedin as the finalists have been contacted and now we await for the final winner to this year's Award!

Submit your email now to recieve a reminder ahead of time for the next award:

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HyperCAM Alpha

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3Brain's multiwell microelectrode array: The HyperCAM Alpha.
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HyperCAM Alpha

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BioCAM DupleX

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3Brain's bidirectional single-well HD MEA - BioCAM DupleX3Brain's bidirectional single-well HD MEA - BioCAM DupleX

BioCAM DupleX

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BioCAM DupleX

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BioCAM DupleX

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HyperCAM Alpha

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HyperCAM Alpha

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Single-Well
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Multiwell
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Software
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Accessories
The only fully bi-directional HD-MEA (microelectrode array) platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in vitro electrophysiology.

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Our genuine HD-MEA (microelectrode array) platform with everything you need for in vitro neuronal physiology. - BioCAM X

BioCAM X

Our genuine HD-MEA platform with everything you need for in vitro neuronal physiology.

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Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

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HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

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CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

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BrainWave 4

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

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IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Created with Sketch.
Single-Well
Created with Sketch.
Multi-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
The only fully bi-directional high density microelectrode array platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more

Single-Well HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more

BrainWave

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Created with Sketch.
Single-Well
Created with Sketch.
Multi-Well
Created with Sketch.
Software
Created with Sketch.
Accessories
The only fully bi-directional high density microelectrode array platform for 2D and 3D in vitro electrophysiology.

BioCAM DupleX

The only fully bi-directional HD-MEA platform for 2D and 3D in-vitro electrophysiology.

Discover more

BioCAM X

Our genuine high-end HD-MEA platform with everything you need for in-vitro neuron physiology.

Discover more

Single-Well
HD-MEAs

A varied selection of high-density MEAs to match your precise research needs.

Discover more

HyperCAM Alpha

The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations.

Discover more

CorePlate™ Multiwells

The CorePlate™ technology’s processing capabilities convert the multiwell plates into smart objects.

Discover more

BrainWave

The companion of our single-well HD-MEAs to visualize, record, and analyze cell activity in real-time.

Discover more
IO Connector Box - 3Brain Accessories: featuring multiple modules for the CMOS-MEA channels

Single-Well Accessories

Expand the possibilities of the single-well BioCAM systems.

Discover more
Our Mission

3Brain strives to provide researchers with breakthrough technology to improve the understanding of organs and their related illnesses.

3Brain strives to provide researchers with breakthrough technology to improve the understanding of organs and their related illnesses.

How can 3Brain products boost your data?

From the bench to the paper

1

Simplifying experimental setups into an all-in-one compact design, including an advanced and user friendly acquisition and analysis software

1

Simplifying experimental setups into an all-in-one compact design, including an advanced and user friendly acquisition and analysis software

See the BioCAM DupleX

2

Getting a deeper understanding of neuronal networks using a sensitive technology providing a superior spatial and temporal resolution

2

Getting a deeper understanding of neuronal networks using a sensitive technology providing a superior spatial and temporal resolution

See CorePlate™ technology

3

Obtaining clearer and more reliable statistics while requiring less experiments - all in a time efficient manner

3

Obtaining clearer and more reliable statistics while requiring less experiments - all in a time efficient manner

See latest publications

Resources

See our MEA neuro-imaging technology in action

Explore the capabilities of our neuron processors (also known as high density microelectrode arrays - HD-MEAs) and our software tools: take a look at these experimental data samples and download the free version of BrainWave.

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Latest News

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March 25, 2021

Ribbon Synapses Seminar Series 2021

Register for the first Ribbon Synapses Seminar Series 2021 today!
Today's session is focusing on the inner ear (auditory, balance and spatial orientation systems): first enjoy the musical talents of Empire Wild with Ken Kubota, Mitch Lyon and Brandon Ilaw - proudly sponsored by 3Brain AG, followed by a brief introduction from our very own, Sercan Deniz.
Then learn about how we encode sounds and process them in the auditory system with Tobias Moser, from Universitätsmedizin Göttingen, and Katja Bleckmann from Carl von Ossietzky University of Oldenburg. Ruth Anne Eatock from the University of Chicago will then enter into the details of the balance system in the inner ear.

Jointly hosted by Washington University School of Medicine in St. Louis and the Collaborative Research Center of Universitätsmedizin Göttingen.

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February 12, 2021

New publication : "A claustrum in reptiles and its role in slow-wave sleep"

In this exciting paper from Norimoto et al., researchers from the Gilles Laurent lab at Max Planck Institute for Brain Research, Frankfurt am Main deciphered the function of a not so well known brain structure, the claustrum, showing how it is involved in the control of brain activity during sleep cycles. Our HD-MEAs helped measure the in vitro propagation velocity of the sharp-wave ripples (SWRs) generated in the claustrum of a reptile (the Australian bearded dragon Pogona vitticeps) during sleep.

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March 3, 2021

Collaboration with a:head bio AG

Today we'd like to announce our official collaboration with a:head bio AG on the development of 3Brain’s next generation microelectrode array (MEA): the CorePlate ™ technology.
With this collaboration we intend to improve the technology to allow for extraction of highly resolved electric signals from 3D biology in an automated, high-throughput work flow.

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Latest Publication

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Neuronal Cultures
Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Acute Brain Slices
Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions

Ixmatlahua D. J., Vizcarra B., Gómez-Lira G., Romero-Maldonado I., Ortiz F., Rojas-Piloni G. and Gutiérrez R.

The Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.2590-19.2020

Acute Retina
Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

Zerti D., Hilgen G., Dorgau B., Collin J., Ader M., Armstrong L., Sernagor E., and Lako M.

Stem Cells Journal (2021). DOI: https://doi.org/10.1002/stem.3365

Organoids
Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

Latest Publications

View all  
Neuronal Cultures
Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Acute Brain Slices
Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions

Ixmatlahua D. J., Vizcarra B., Gómez-Lira G., Romero-Maldonado I., Ortiz F., Rojas-Piloni G. and Gutiérrez R.

The Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.2590-19.2020

Acute Retina
Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

Zerti D., Hilgen G., Dorgau B., Collin J., Ader M., Armstrong L., Sernagor E., and Lako M.

Stem Cells Journal (2021). DOI: https://doi.org/10.1002/stem.3365

Organoids
Room temperature shipment does not affect the biological activity of pluripotent stem cell derived retinal organoids

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

Neuronal Cultures

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Acute Brain Slices

Ixmatlahua D. J., Vizcarra B., Gómez-Lira G., Romero-Maldonado I., Ortiz F., Rojas-Piloni G. and Gutiérrez R.

The Journal of Neuroscience (2020). DOI: https://doi.org/10.1523/JNEUROSCI.2590-19.2020

Acute Retina

Zerti D., Hilgen G., Dorgau B., Collin J., Ader M., Armstrong L., Sernagor E., and Lako M.

Stem Cells Journal (2021). DOI: https://doi.org/10.1002/stem.3365

Organoids

Georgiou M., Chichagova V., Hilgen G., Dorgau B., Sernagor E., Armstrong L. and Lako M.

Plos One (2020). DOI: https://doi.org/10.1371/journal.pone.0233860

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