Gallery

Activity footprints of a ganglion cell (top) and a polyaxonal amacrine cell (bottom) from an ex-vivo mouse retina showing single (ganglion cell) and multiple (amacrine cell) axonal propagations.

Recording of light-elicited activity of salamander retinal ganglion cells.

Recording of spontaneous electrophysiological activity from the ganglion cell layer in the Cone Rod Homeobox knockout mouse retina, a model of photoreceptor dystrophy. Dystrophic retinas are characterized by pathological, strong spontaneous bursting and oscillations in the ganglion cell layer. In this example, bursts are generated in cell bodies and propagate along axons converging toward the optic disc.

Spontaneous waves recorded from the ganglion cell layer in a P11 mouse retina. The activity becomes stronger in the presence of the GABA-A receptor antagonist bicuculline (10 µM) and furosemide (100 µM), a blocker of the potassium-chloride co-transporter KCC2.

Light-elicited ganglion cell responses of a mouse retina (P113) showing the activity of retinal ON ganglion cells after onset of a full field light stimulus (2.8 cd*s/m2). Immediately after stimulus onset, ON transient ganglion cell types respond to the light followed by more ON sustained ganglion cell types. The optic disc is in the middle, the dorsal side at the bottom and the ventral side at the top.

Retinal ganglion cell axonal responses to flickering (1Hz) checkerboard stimulus under dark mesopic conditions. The recording clearly shows propagating impulses along axonal bundles (P113 days mouse).