Brain Slice Electrophysiology

Boost neuronal circuitry studies through functional brain tissue imaging

Models

  • Acute brain slices

  • Organotypic brain slices

Advantages

Our single-well and multi-well CorePlate™ can record both spiking activity and field potential propagations (fEPSP, Population Spikes) over different regions in brain tissue preparations at unprecedented spatial and temporal resolutions.

Advantages of 3Brain technology with brain slice imaging are:

  • Large brain region monitoring of spontaneous activity patterns and precise mapping of activity propagation over multiple circuits

  • Precise electrical stimulation capability

  • Automated LTP/LTD protocols for plasticity studies.

  • Finely resolve signals from dendritic compartments or somatic layers within sub-areas of the circuitry

Click here to know how the technology works

Tools & Features

Brain Slices - Integrated spike/LFP detection and sorting algorithms
  • Integrated spike/LFP detection and sorting algorithms

    Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity

Feel free to get in contact with our neuroscientists team for details

Contact Us

Customer experience

A collection of reviews from our customers

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Publications

View all  
Acute Brain Slices
A novel prefrontal cortex and hippocampus combined brain slice based on in vivo diffusion tensor imaging of healthy male rats

(paper)

Lijun Zhang, Qian Zhou, Guanghao Zhang, Changzhe Wu, Wei Rong, Shiji He, Xiaolin Huo, Cheng Zhang

Neurosci. Lett. (2025). DOI: 10.1016/j.neulet.2025.138171.

Acute Brain Slices
Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model

(paper)

Fabiana Santana Kragelund, Konstantinos Spiliotis, Marco Heerdegen, Tina Sellmann, Henning Bathel, Anika Lüttig, Angelika Richter, Jens Starke, Rüdiger Kohling, Denise Franz

Neurobiol. Dis. (2025). DOI: 10.1016/j.nbd.2024.106779

Acute Brain Slices
High-Quality Seizure-Like Activity from Acute Brain Slices Using a Complementary Metal-Oxide-Semiconductor High-Density Microelectrode Array System

(paper)

Blotter, M. L., Stubbs, I. W., Norby, J. H., Holmes, M., Kearsley, B., Given, A., Hine, K., Shepherd, M. R., Parrish, R. R.

J. Vis. Exp. (2024). DOI:10.3791/67065

Acute Brain Slices
Milestone White Paper 1

(white paper)

Cradle

Cradle. (2024).

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