Brain Slice Electrophysiology

Boost neuronal circuitry studies through functional brain tissue imaging

Models

  • Acute brain slices

  • Organotypic brain slices

Advantages

Our single-well and multi-well CorePlate™ can record both spiking activity and field potential propagations (fEPSP, Population Spikes) over different regions in brain tissue preparations at unprecedented spatial and temporal resolutions.

Advantages of 3Brain technology with brain slice imaging are:

  • Large brain region monitoring of spontaneous activity patterns and precise mapping of activity propagation over multiple circuits

  • Precise electrical stimulation capability

  • Automated LTP/LTD protocols for plasticity studies.

    See Evos

  • Finely resolve signals from dendritic compartments or somatic layers within sub-areas of the circuitry

Click here to know how the technology works

Tools & Features

Brain Slices - Integrated spike/LFP detection and sorting algorithms
  • Integrated spike/LFP detection and sorting algorithms

    Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity

Real-time and off-line filtering capabilities from fast spiking activities - 3Brain
  • Real-time and off-line filtering capabilities

    A complete set of different filters (high pass, low pass and band pass) can be selected to separate slow field waves from fast spiking activity

Superimpose and Focus on BrainWave - 3Brain
  • Superimpose and Focus

    Tissue sample image can be superimposed on the activity map to record selected region of interests or to focus on a specific area of activity for advanced analysis

Built-in stimulating capabilities with the BrainWave software - 3Brain
  • Built-in stimulating capabilities

    Electrically evoked field potential responses can be investigated by using the internal stimulator of the BioCAM systems

Feel free to get in contact with our neuroscientists team for details

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Resources

3Brain's 24-well HD-MEA, HyperCAM Delta.
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