Boost neuronal circuitry studies through functional brain tissue imaging
Acute brain slices
Organotypic brain slices
Our single-well HD-MEAs and CorePlate™ multiwells can record both spiking activity and field potential propagations (fEPSP, Population Spikes) over different regions in brain tissue preparations at unprecedented spatial and temporal resolutions.
Advantages of 3Brain technology with brain slice imaging are:
Large brain region monitoring of spontaneous activity patterns and precise mapping of activity propagation over multiple circuits
Precise electrical stimulation capability
Automated LTP/LTD protocols for plasticity studies.
Finely resolve signals from dendritic compartments or somatic layers within sub-areas of the circuitry
Click here to know how the technology works
Integrated spike/LFP detection and sorting algorithms
Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity
Real-time and off-line filtering capabilities
A complete set of different filters (high pass, low pass and band pass) can be selected to separate slow field waves from fast spiking activity
Superimpose and Focus
Tissue sample image can be superimposed on the activity map to record selected region of interests or to focus on a specific area of activity for advanced analysis
Feel free to get in contact with our neuroscientists team for detailsContact Us
A collection of reviews from our customers
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
Dr. Ryley ParrishXenon Pharmaceuticals Inc.
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.
Prof. Alysson MuotriInstitute for Genomic Medicine
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
Prof. Kim SangSeongHanyang University College of Pharmacy
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
Location to specific products and samples within 3Brain's resources
Biosensors and Bioelectronics (2022). DOI: 10.1016/j.bios.2021.113834
Cells (2022). DOI: 10.3390/cells11061047
Mol Neurobiol. (2021). DOI: 10.1007/s12035-021-02502-x
eLife (2021) DOI: 10.7554/eLife.65712