The 3Brain -
Massimo Grattarola Award
Application Info

Neuronal cell culture and stem cell cultures

Explore new pathways in brain research and drug discovery

Models

  • Human iPSC-derived neuronal culture

  • Neural progenitor derived cultures

  • Primary neuronal cell culture

Advantages

Our single-well HD-MEAs and multiwell CorePlate™, based on high density microelectrode array technology, allow studying of the physiological and pathological functional activity of neuronal cultures. A versatile tool to investigate in detail the mechanisms of neuronal signal processing and to improve the quality and reliability of drug screenings or toxicological assays.

Advantages of using 3Brain technology on neuronal cultures:

  • Label-free functional monitoring of large networks with single-cell spiking activity resolution

  • Tracking of signal propagation among cells for functional connectivity studies

  • Kinetic functional assay to follow culture development over weeks and months

  • Improved statistical significance of the calculated network activity parameters

Click here to know how the technology works

Tools & Features

Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity - 3Brain
  • Integrated spike detection and sorting algorithms

    Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity

Automated statistical analysis of network parameters - 3Brain
  • Automated statistical analysis of network parameters

    The all-in-one BrainWave software will assist you in quickly obtaining results from your experimental session in a simple and intuitive way

  • Built-in stimulating capabilities

    Investigate electrically evoked neural network responses by using the internal stimulator of the BioCAM systems and HyperCAM systems

Feel free to get in contact with us regarding demos or further details customized

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Customer experience

A collection of reviews from our customers

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

FinalSpark
Fred Jordan's 3Brain review
The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Prof. Alysson Muotri's 3Brain review
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Selected Publications

View all  
Neuronal Cultures
A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

(paper)

Cutarelli A., Martínez-Rojas V.A., Tata A., Battistella I., Rossi D., Arosio D., Musio C., and Conti L.

MDPI (2021). DOI: https://doi.org/10.3390/cells10051127

Neuronal Cultures
Transfer Entropy Based Connectivity Estimation of Spontaneously Firing Hippocampal Cultures on Multi Electrode Arrays

(conf. proc.)

Lama N., Hargreaves A.J., Stevens B., Mcginnity T.M.

International Joint Conference on Neural Networks (2019). DOI: 10.1109/IJCNN.2019.8851864

Neuronal Cultures
State-dependent representation of stimulus-evoked activity in high-density recordings of neural cultures

(paper)

Nieus T., D’Andrea V., Amin H., Di Marco S., Safaai H., Maccione A., Berdondini L. and Panzeri S.

Scientific Reports (2018). DOI: 10.1038/s41598-018-23853-x

Our neuroscientist team is here to assist you with your application needs with our products.
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