Empower your cardiac safety screening with accurate label-free functional imaging
Primary cardiomyocytes culture
Human induced pluripotent stem cell derived cardiomyocytes
Explanted heart tissue
The rise of human pluripotent stem cells (hPSCs) derived cardiomyocytes brings a promising new dimension to cardiac safety assays, a mandatory step in the development of new drugs.
With thousands of simultaneously recording electrodes, our single-well HD-MEAs and CorePlate™ multiwells can record cardiac cell rhythm and other parameters, such as QT-interval duration, contraction (beat) period, signal amplitude, and propagation velocity at an unprecedented spatial and temporal resolution by providing:
Label-free, non-invasive functional monitoring of cardiac cells’ electrical activity
High sampling rate (20 kHz) and high spatial resolution for a more accurate and detailed description of the cardiac signal propagation
Kinetic functional assay to observe culture development over days to weeks, suitable for long-term toxicity studies
High statistical significance of the waveform parameters
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Location to specific products and samples within 3Brain's resources
(selected papers)
Nature Nanotechnology (2018). DOI: https://doi.org/10.1038/s41565-018-0222-z
(selected papers)
IEEE Trans Biomed Eng. (2008). DOI: 10.1109/TBME.2008.919139.