Cardiomyocytes

Empower your cardiac safety screening with accurate label-free functional imaging

Models

  • Primary cardiomyocytes culture

  • Human induced pluripotent stem cell derived cardiomyocytes

  • Explanted heart tissue

Advantages

The rise of human pluripotent stem cells (hPSCs) derived cardiomyocytes brings a promising new dimension to cardiac safety assays, a mandatory step in the development of new drugs.

With thousands of simultaneously recording electrodes, our single-well HD-MEAs and CorePlate™ multiwells can record cardiac cell rhythm and other parameters, such as QT-interval duration, contraction (beat) period, signal amplitude, and propagation velocity at an unprecedented spatial and temporal resolution by providing:

  • Label-free, non-invasive functional monitoring of cardiac cells’ electrical activity

  • High sampling rate (20 kHz) and high spatial resolution for a more accurate and detailed description of the cardiac signal propagation

  • Kinetic functional assay to observe culture development over days to weeks, suitable for long-term toxicity studies

  • High statistical significance of the waveform parameters

Click here to know how the technology works

Tools & Features

Integrated cardiac signal detection algorithms - 3Brain
  • Integrated cardiac signal detection algorithms

    Different cardiac signal detectors are available in BrainWave software to extract and classify relevant parameters

Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte activity - 3Brain
  • Real time analysis

    Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte activity

With built-in stimulating capabilities - 3Brain
  • Built-in stimulating capabilities

    Electrically evoked responses can be investigated by using the internal stimulator of the BioCAM systems and HyperCAM systems.

Feel free to get in contact with us regarding demos or further details

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Customer experience

A collection of reviews from our customers

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Selected Publications

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Cardiomyocyte

Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

(paper)

Iachetta G., Colistra N., Melle G., Deleye L., Tantussi F., Angelis F.D., and Dipalo M.

Toxicology and Applied Pharmacology (2021). DOI: https://doi.org/10.1016/j.taap.2021.115480

Cardiomyocyte
Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

(paper)

Dipalo M., Melle G., Lovato L., Jacassi A., Santoro F., Caprettini V., Schirato A., Alabastri A., Garoli D., Bruno G., Tantussi F., De Angelis F.

Nature Nanotechnology (2018). DOI: https://doi.org/10.1038/s41565-018-0222-z

Our neuroscientist team is here to assist you with your application needs with our products.
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