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The 3Brain -
Massimo Grattarola Award
Application Info

Cardiomyocyte Cells

Perform in vitro electrocardiograms to gain functional and spatiotemporal insights from cardiac cells. Record electrophysiological activity in cardiomyocytes cultures, cardiac spheroids, and cardiac organoids.

Models

  • Primary cardiomyocytes culture

  • Human induced pluripotent stem-cell derived cardiomyocytes

  • Explanted heart tissue

Advantages

The rise of human pluripotent stem cells (hPSCs)-derived cardiomyocytes brings a promising new dimension to cardiac safety assays, a mandatory step in the development of new drugs.

With thousands of simultaneously recording electrodes, our single-well HD-MEAs and CorePlate™ multiwells can record cardiac cell rhythm and other parameters, such as QT-interval duration, contraction (beat) period, signal amplitude, and propagation velocity at an unprecedented spatial and temporal resolution by providing:

  • Label-free, non-invasive functional monitoring of cardiac cells’ electrical activity

  • High sampling rate (20 kHz) and high spatial resolution for a more accurate and detailed description of the cardiac signal propagation

  • Kinetic functional assay to observe culture development over days to weeks, suitable for long-term cardiac toxicology studies

  • High statistical significance of the waveform parameters

Click here to know how the technology works

Tools & Features

Integrated cardiac signal detection algorithms - Different cardiac signal detectors are available in BrainWave software to extract and classify relevant parameters
  • Integrated cardiac signal detection algorithms

    Different cardiac signal detectors are available in BrainWave software to extract and classify relevant parameters

Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte activity - 3Brain
  • Real time analysis

    Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte cell activity

With built-in stimulating capabilities - 3Brain
  • Built-in stimulating capabilities

    Electrically evoked responses can be investigated by using the internal stimulator of the BioCAM systems and HyperCAM systems.

Feel free to get in contact with our neuroscientists team for details

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Customer experience

A collection of reviews from our customers

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Selected Publications

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Cardiomyocyte

Multi-chamber cardioids unravel human heart development and cardiac defects

(paper)

Schmidt C., Deyett A., Ilmer T., Haendeler S., Caballero A. T., Novatchkova M., Netzer M. A., Ginistrelli L. C., Juncosa E. M., Bhattacharya T., Mujadzic A., Pimpale L., Jahnel S. M., Cirigliano M., Reumann D., Tavernini K., Papai N., Hering S., Hofbaur P., Mendjan S.

Cell (2023) DOI: 10.1016/j.cell.2023.10.030

Cardiomyocyte
All-Optical and Label-Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials

(paper)

Bruno G. , Melle G. , Barbaglia A. , Iachetta G., Melikov R., Perrone M., Dipalo M., and Angelis F.D.

Advanced Science (2021). DOI: 10.1002/advs.202100627

Do you want to know more?
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