Cardiomyocyte Cells

Perform in vitro electrocardiograms to gain functional and spatiotemporal insights from cardiac cells. Record electrophysiological activity in cardiomyocytes cultures, cardiac spheroids, and cardiac organoids.

Models

Primary cardiomyocytes culture
Human induced pluripotent stem-cell derived cardiomyocytes
Explanted heart tissue

Advantages

The rise of human pluripotent stem cells (hPSCs)-derived cardiomyocytes brings a promising new dimension to cardiac safety assays, a mandatory step in the development of new drugs.

With thousands of simultaneously recording electrodes, our single-well and multiwell CorePlate™ can record cardiac cell rhythm and other parameters, such as QT-interval duration, contraction (beat) period, signal amplitude, and propagation velocity at an unprecedented spatial and temporal resolution by providing:

Label-free, non-invasive functional monitoring of cardiac cells’ electrical activity
High sampling rate (20 kHz) and high spatial resolution for a more accurate and detailed description of the cardiac signal propagation
Kinetic functional assay to observe culture development over days to weeks, suitable for long-term cardiac toxicology studies
High statistical significance of the waveform parameters

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Tools & Features

Integrated cardiac signal detection algorithms - Different cardiac signal detectors are available in BrainWave software to extract and classify relevant parameters

Integrated cardiac signal detection algorithms
Different cardiac signal detectors are available in BrainWave software to extract and classify relevant parameters

Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte activity - 3Brain

Real time analysis
Performing real time analysis of entire network activity and live quantification of phenotypic changes in cardiomyocyte cell activity

With built-in stimulating capabilities - 3Brain

Built-in stimulating capabilities
Electrically evoked responses can be investigated by using the internal stimulator of the BioCAM systems and HyperCAM systems.

Feel free to get in contact with our neuroscientists team for details

Customer experience

A collection of reviews from our customers

The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Michele Dipalo, PhD

Plasmon Nanotechnologies group at the Italian Institute of Technology (IIT)Link to Author’s Publication

The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.

Dr. Matthias H. Hennig

Computational Neuroscience and Neuroinformatics Link to Author’s Publication

Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.

Prof. Egidio D’Angelo

University of Pavia Link to Author’s Publication

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.

Prof. Evelyne Sernagor

Retinal Neuroscience Link to Author’s Publication

It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

FinalSpark Link to Author’s Publication

3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.

Dr. Ryley Parrish

Xenon Pharmaceuticals Inc.Link to Author’s Publication

We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.

Dr. Hayder Amin

Biohybrid Neuroelectronics Lab Link to Author’s Publication

I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.

Prof. Kim SangSeong

Hanyang University College of Pharmacy Link to Author’s Publication

Resources

Location to specific products and samples within 3Brain's resources

Selected Publications

View all

Cardiomyocyte

Multi-chamber cardioids unravel human heart development and cardiac defects

(paper)

Schmidt C., Deyett A., Ilmer T., Haendeler S., Caballero A. T., Novatchkova M., Netzer M. A., Ginistrelli L. C., Juncosa E. M., Bhattacharya T., Mujadzic A., Pimpale L., Jahnel S. M., Cirigliano M., Reumann D., Tavernini K., Papai N., Hering S., Hofbaur P., Mendjan S.

Cell (2023) DOI: 10.1016/j.cell.2023.10.030

Cardiomyocyte

Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation

(paper)

Inácio JM, Nunes MM, Almeida M, Cristo F, Anjos R, Belo JA.

Cells. 2023; 12(4):520. DOI: 10.3390/cells12040520

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Cardiomyocyte Cells

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Selected Publications

Cardiomyocyte

Multi-chamber cardioids unravel human heart development and cardiac defects

Multi-chamber cardioids unravel human heart development and cardiac defects

Cardiomyocyte

Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation

Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation

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