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BrainWave 6
This image shows off the powerful Brainwave6 software interface and how it is used in neuroscience research to analyze brain cell activity.

Key Properties

Built for CorePlate™. From Recording to Insight. Fast, Scalable, Seamless.

Designed for analyzing data from CorePlate™ 1, 6, 24 & 96 well HD‑MEAs
Unified 3-in-1 software: Record, Playback, Analyze
Streamlined automation - from acquisition to reporting
Enhanced intra-well area analysis for multiple spheroids & organoids per well
Scalable for multi-plate, high-throughput workflows
Compatible with all our systems; supports robotic automation with HyperCAM Delta
Visualize your data with hundreds of available metrics
This animated activity map, generated with 3Brain's BrainWave6 software, provides a real-time view of neural firing in two brain organoids on a high-density multi-electrode array (HD-MEA). The dynamic heatmap visualizes the mean firing rate, allowing researchers to instantly observe the spatio-temporal dynamics of their neural networks and see precisely how and where activity propagates across the culture.

BrainWave 6

Applications & Highlights

High-Throughput spheroid & organoid screening

Record from up to 100 spheroids per 24 well plate simultaneously.

Efficient compound screening in neuronal cultures

Screen your compounds effectively and establish robust electrophysiological responses to compounds with simultaneous recording from all electrodes and all wells. Visualize PCA plots & UMAP of your control & treated data.
A scatter plot produced from Brainwave 6.

BrainWave 6

Other models

Neuronal Cultures (primary, iPSC etc.)
Brain Organoids & 3D Neuronal Cultures
Brain Slices (cerebellar, hippocampal etc.)
Explanted Retina (mouse, zebrafish etc.)
Cardiomyocytes & Cardioids

BrainWave 6

Modules

All in one Software

Recorder
Visualize real-time HD-MEA data of up to 24 wells
Full control of experimental setup and timing
Playback
Navigate recordings across time points or sessions
Review raw or processed data instantly
Annotate events directly within the software
Analysis
Hundreds of available metrics for neuronal and cardiac activity
Area-based intra-well segmentation for multi- spheroid & organoid analysis
AI-enhanced spike and detection
A composite image showcasing the versatile interface of the 3Brain BrainWave 6 software, a platform designed for analyzing data from high-density multi-electrode arrays (HD-MEAs).

Automation

Automation Compatible
With BrainWave  6, automation is possible at every stage of your workflow, making electrophysiological screening faster and more efficient.
Hands-free recording & data reporting
Once your experimental parameters are defined, let BrainWave 6 take over. Recording, analysis, and reporting are handled automatically, allowing you to focus on your research rather than routine tasks.
Robotic plate handling
When paired with the HyperCAM Delta, BrainWave 6 enables the seamless integration of robotic plate handlers to fully automate workflows, reduce manual intervention and increase throughput.
This shows the possibility of Brainwave6 supporting robotic automation in combination with HyperCAM Delta.

Add-on

What is it?
Our solution for easily performing and analyzing long-term potentiation (LTP) experiments in hippocampal brain slices on the BioCAM Duplex, and the HyperCAM Alpha.
Automated LTP protocols
Run consistent, reproducible stimulation protocols (LTP, LTD, paired pulse) without the need for extensive manual timing, external tools or programming.
Real Time Readouts
Instant visualization and analysis of field potential recordings.
Focus on Discovery, Not Setup
Save hours in setup, BrainWave 6 handles the protocol, so you can focus on the data.
The infographic effectively demonstrates how a brief, high-frequency electrical event can cause a long-lasting enhancement of synaptic communication, a process central to brain function.

BrainWave 6

Data & Exporting

Comprehensive output formats for streamlined external analysis

Export your data in HDF5 format for compatibility with Python, MATLAB, and other external analysis tools. Generate publication-ready outputs, including charts, raster plots, videos, and PDF reports, to support rigorous scientific documentation and review.
A vibrant medical illustration of a neural network, showing interconnected neurons (brain cells) firing.
CULTURE
An abstract visualization of raw neural signals.
RECORD
Visualization of neuroscience experimental reports from the 3Brain BrainWave 6 platform.
AUTOMATED REPORT
Get clearer insights from your HD-MEA data in less time. Curious how?
Contact us to see it in action

Explore The platforms compatible with BrainWave 6

BioCAM Duplex

Discover more

HyperCAM Alpha

Discover more

HyperCAM Delta

Discover more

Can't find what you're looking for? No worries!
Reach out to us—our team is here and happy to help.
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Neuronal & Stem Cell CulturesBrain Organoids & 3D Neuronal CulturesBrain SlicesExplanted RetinaPharma on ChipCardiomyocytes
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Huobstrasse 16, 8808 Pfäffikon, Switzerland
Copyright © 2025 3Brain AG. All rights reserved.
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Apply now:
The Massimo Grattarola Award 2025
Products
Single-Well
Multi-well
Software
Others
About Us
Our StoryOur TeamInnovation NetworkCareersEventsLocations
Applications
Neuronal & Stem Cell CulturesBrain Organoids & 3D Neuronal CultureBrain SlicesExplanted RetinaCardiomyocytesPharma on Chip
Resources
Technical DocumentationUser Guide VideosSoftware Documentation & Add-onPublicationsCorePlate™ Example RecordingsMEA Knowledge Hub
Technology
CorePlate™ 3DCorePlate™ Technology
Huobstrasse 16, 8808 Pfäffikon, Switzerland
Find Distributor
Copyright © 2025 3Brain AG. All rights reserved.
Icon Rounded Closed - BRIX Templates
Apply now:
The Massimo Grattarola Award 2025