Shed light on retinal activity in vitro. Record responses to light stimuli and generate retinal ganglion cells (RGCs) mosaics.
Whole mount retina explants
Primate and non-primate retina tissues
Explanted retinas from different animal models (e.g. murine, salamander, primates, etc.) can be studied up-close on our single-well HD-MEAs or CorePlate™ multiwells. With the largest active microelectrode area on the market (up to 25mm²), they are optimized for recording single cell activity over large tissue samples.
Advantages of 3Brain technology with explanted retinas are:
Entire retinal ganglion cell network mapping at single-cell resolution.
Record light-induced retinal network activity by combining our BioCAM platform with light-stimulation devices.
Combine with optogenetic stimulation tools for spatiotemporally precise excitation/inhibition of cells
Single cell visualization of signal propagation
Click here to know how the technology works
Integrated spike/LFP detection and sorting algorithms
Run sophisticated analyses like spike-sorting to evaluate your results for statistical significance with BrainWave, our most elaborated retinal electrophysiology data analysis software.
Full compatibility with third-party softwares
HDF5 file format raw data readable with Python, Igor Pro, Matlab…Run your custom home made analysis routines.
Feel free to get in contact with our neuroscientists team for detailsContact Us
A collection of reviews from our customers
The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.
Prof. Alysson MuotriInstitute for Genomic Medicine
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
Prof. Kim SangSeongHanyang University College of Pharmacy
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
Dr. Ryley ParrishXenon Pharmaceuticals Inc.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.
Location to specific products and samples within 3Brain's resources
ACS Nano (2023) DOI: 10.1021/acsnano.3c07517
Nature Communications (2023). DOI: 10.1038/s41467-023-41032-z