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Application Info

Ex-vivo acute retinal explant

Shed light on retinal activity in vitro. Record responses to light stimuli and generate retinal ganglion cells (RGCs) mosaics.


  • Whole mount retina explants

  • Primate and non-primate retina tissues


Explanted retinas from different animal models (e.g. murine, salamander, primates, etc.) can be studied up-close on our single-well or multiwell CorePlate™. With the largest active microelectrode area on the market (up to 25mm²), they are optimized for recording single cell activity over large tissue samples.

Advantages of 3Brain technology with explanted retinas are:

  • Entire retinal ganglion cell network mapping at single-cell resolution.

  • Record light-induced retinal network activity by combining our BioCAM platform with light-stimulation devices.

  • Combine with optogenetic stimulation tools for spatiotemporally precise excitation/inhibition of cells

  • Single cell visualization of signal propagation

Click here to know how the technology works

Tools & Features

Different spike detection and sorting techniques are available in BrainWave software to extract and classify relevant cell activity - 3Brain
  • Integrated spike/LFP detection and sorting algorithms

    Run sophisticated analyses like spike-sorting to evaluate your results for statistical significance with BrainWave, our most elaborated retinal electrophysiology data analysis software.

the HDF5 file format of BrainWave  is fully compatibile with third-party softwares - 3Brain
  • Full compatibility with third-party softwares

    HDF5 file format raw data readable with Python, Igor Pro, Matlab…Run your custom home made analysis routines.

3Brain's BrainWave software also synchronizes a light stimulator with our BioCAM systems - 3Brain
  • Synchronize light stimulator with BioCAM systems

    Analog inputs or triggers (LV-TTL) lines can be used to synchronize and record light stimulation patterns with the BioCAM’s dataset.

Feel free to get in contact with our neuroscientists team for details

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Customer experience

A collection of reviews from our customers

The BioCAM has revolutionized the way we look at population activity in the retina. With its overall large size and spatial resolution, it allows us to study population behaviour at unprecedented spatial and temporal detail.
The BioCAM offers, for the first time, recordings at a scale that allow validation of models of neuronal population activity. This is a major step that will drive, in turn, the development of theories in neuroscience.
Our laboratory works on brain experimental recordings and modeling on multiple scales, from molecular/cellular to whole brain in animals and humans. The use of BioCAM X integrates perfectly into the workflow as it allows a unique set of measurements on distributed network activities.
It is a pleasure to work with the 3Brain team, they are both highly skilled experts and friendly.

Dr. Fred Jordan, Co-CEO

Fred Jordan's 3Brain Review
The Muotri lab uses 3Brain high-resolution multi electrode arrays to understand how human neural networks are formed during development, and become altered in several neurological conditions.

Prof. Alysson Muotri

Institute for Genomic Medicine
Prof. Alysson Muotri's 3Brain Review
We engineer a novel plasticity neuroelectronic platform using CMOS-MEA, nano-microtechnology and computational tools to decipher the molecular and functional plasticity simultaneously in a large-scale circuit/network in health and disease.
I have conducted a wide range of brain slices as well as neuron culture experiments in 3Brain's HD MEA system. Their technology is beyond expectation in terms of sensitivity, durability, and high STN ratio.
3Brain has impressed me with the quality of its products. The BioCAM DupleX has been the perfect platform to aid our drug discovery efforts at Xenon, and the personal one-on-one assistance continues to exceed my expectations.
The HD MEAs allow us to perform accurate cardiotoxicity assessments on hiPS cardiomyocytes by applying a novel laser technology for recording high-quality action potentials from thousands of cardiac cells simultaneously.

Selected Publications

View all  
Acute Retina
Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration


Cupini S, Di Marco S, Boselli L, Cavalli A, Tarricone G, Mastronardi V, Castagnola V, Colombo E, Pompa PP, Benfenati F.

ACS Nano (2023) DOI: 10.1021/acsnano.3c07517

Acute Retina
Birds multiplex spectral and temporal visual information via retinal On- and Off-channels


Seifert M., A. Roberts P., Kafetzis G., Osorio D. and Baden T.

Nature Communications (2023). DOI: 10.1038/s41467-023-41032-z

Acute Retina
Glial Bmal1 role in mammalian retina daily changes


Riccitelli S., Boi F., Lonardoni D., Giantomasi L., Barca-Mayo O., De Pietri Tonelli D., Bisti S., Di Marco S. and Berdondini L.

Scientific Reports (2022). DOI: 10.1038/s41598-022-25783-1

Do you want to know more?
Book a chat or email us, as our neuroscientist team is here to assist you.
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