Tech Specs

High-density microelectrode arrays with large sensing areas

Our high-density microelectrode array (HD-MEA), also known as multielectrode array, features 4,096 low-noise microelectrodes that allow for simultaneous electrophysiological recording.

Overview

The perfect tool for your brain research

Investigating cellular networks often requires time, expertise and efforts to obtain the performance necessary to validate research hypotheses. With 3Brain as your technology partner, you will be able to easily capture every cell signal in high resolution.

Our powerful multielectrode array (HD-MEA) collects high-density electrophysiological data from preparations made of brain slices, neuronal tissue, human-derived stem cells, brain organoids, retinal tissue and cardiac cultures/tissues.

Different HD-MEA chip models for our microelectrode arrays are available to match your experimental needs in terms of resolution, field of view and stimulation capabilities.

Electrodes are coated with platinum to provide a stable and fully biocompatible surface. The quality of the recording is ensured by the outstanding signal-to-noise ratio, as you can see from our video samples gallery.

Recording and stimulating capabilities
for all your applications

HD-MEA Accura

Accura micreoelectrode array features 4096 recording electrodes arranged in a 3.8 mm x 3.8 mm area, a perfect compromise for both cultures and brain tissues. Compared to the previous chipset families, Accura achieves an improved signal to noise ratio by offering a recording mode where a subset electrode area can be accessed for ultra-low noise performances.

Moreover, every single recording electrode can also be used to release an electrical signal to your sample. In this way HD-MEA Accura provides a 3.8 mm x 3.8 mm grid of 4096 electrodes for spatially accurate electrical stimulation at a cellular resolution.

Each microelectrode is 21 µm x 21 µm, with a 60 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Accura is from Khíron (Gen 3) chipset family and can be used with BioCAM DupleX only.

Pre-coated Accura series

Thanks to the AZIGRIP-XXX surface functionalization technology developed in collaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore it provides a homogeneous and reliable adhesion of your cells to the substrate, thus increasing the success rate of your experiments.

At a glance

Recording and stimulating capabilities
for all your applications

HD-MEA Accura

Accura micreoelectrode array features 4096 recording electrodes arranged in a 3.8 mm x 3.8 mm area, a perfect compromise for both cultures and brain tissues. Compared to the previous chipset families, Accura achieves an improved signal to noise ratio by offering a recording mode where a subset electrode area can be accessed for ultra-low noise performances.

Moreover, every single recording electrode can also be used to release an electrical signal to your sample. In this way HD-MEA Accura provides a 3.8 mm x 3.8 mm grid of 4096 electrodes for spatially accurate electrical stimulation at a cellular resolution.

Each microelectrode is 21 µm x 21 µm, with a 60 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Accura is from Khíron (Gen 3) chipset family and can be used with BioCAM DupleX only.

Pre-coated Accura series

Thanks to the AZIGRIP-XXX surface functionalization technology developed in collaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore it provides a homogeneous and reliable adhesion of your cells to the substrate, thus increasing the success rate of your experiments.

At a glance

Recording and stimulating capabilities
for all your applications

HD-MEA Accura

Accura micreoelectrode array features 4096 recording electrodes arranged in a 3.8 mm x 3.8 mm area, a perfect compromise for both cultures and brain tissues. Compared to the previous chipset families, Accura achieves an improved signal to noise ratio by offering a recording mode where a subset electrode area can be accessed for ultra-low noise performances.

Moreover, every single recording electrode can also be used to release an electrical signal to your sample. In this way HD-MEA Accura provides a 3.8 mm x 3.8 mm grid of 4096 electrodes for spatially accurate electrical stimulation at a cellular resolution.

Each microelectrode is 21 µm x 21 µm, with a 60 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Accura is from Khíron (Gen 3) chipset family and can be used with BioCAM DupleX only.

Pre-coated Accura series

Thanks to the AZIGRIP-XXX surface functionalization technology developed in collaboration with SuSoS AG, Accura microelectrode arrays can be provided in a pre-coated, sterile and ready-to-use version for cell cultures. By removing the need for manual functional coating and sterilization, both preparation time and variability in cell cultures between MEAs are reduced. Furthermore it provides a homogeneous and reliable adhesion of your cells to the substrate, thus increasing the success rate of your experiments.

At a glance

More space to accommodate large tissues

HD-MEA Arena

Arena has the same microelectrode recording array as the Prime model (4,096 electrodes in a 2.67 mm x 2.67 mm area), but offers a larger surrounding flat area (~6 mm x 6 mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Arena is from Artemis (Gen2) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

More space to accommodate large tissues

HD-MEA Arena

Arena has the same microelectrode recording array as the Prime model (4,096 electrodes in a 2.67 mm x 2.67 mm area), but offers a larger surrounding flat area (~6 mm x 6 mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Arena is from Artemis (Gen2) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

More space to accommodate large tissues

HD-MEA Arena

Arena has the same microelectrode recording array as the Prime model (4,096 electrodes in a 2.67 mm x 2.67 mm area), but offers a larger surrounding flat area (~6 mm x 6 mm), which is ideal for positioning large tissues while guaranteeing optimal coupling with the microelectrode array.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Arena is from Artemis (Gen2) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

The Stimulo HD-MEA features a large sensing area (5.12 mm x 5.12 mm) with an increased electrode pitch of 81 µm pitch. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining a high spatial resolution.

Moreover, the Stimulo model features a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21 µm x 21 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Stimulo is from Artemis (Gen 2) chipset family and can be used with BioCAM X and  BioCAM Duplex.

At a glance

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

The Stimulo HD-MEA features a large sensing area (5.12 mm x 5.12 mm) with an increased electrode pitch of 81 µm pitch. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining a high spatial resolution.

Moreover, the Stimulo model features a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21 µm x 21 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Stimulo is from Artemis (Gen 2) chipset family and can be used with BioCAM X and  BioCAM Duplex.

At a glance

Largest sensing area and stimulation capabilities

HD-MEA Stimulo

The Stimulo HD-MEA features a large sensing area (5.12 mm x 5.12 mm) with an increased electrode pitch of 81 µm pitch. This makes it possible to record electrophysiological activity from large portions of neuronal tissue while maintaining a high spatial resolution.

Moreover, the Stimulo model features a secondary array for stimulation with 16 microelectrodes, arranged in a 4 x 4 uniform grid, that are interspersed between the recording electrodes.

The electrode size for both recording and stimulating electrodes is 21 µm x 21 µm. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Stimulo is from Artemis (Gen 2) chipset family and can be used with BioCAM X and  BioCAM Duplex.

At a glance

Ideal for cell cultures

HD-MEA Prime

Prime is a high-density microelectrode array integrating 4,096 recording electrodes on a small and compact area of 2.67 mm x 2.67 mm, centered on a flat area of ~3 mm x 3 mm. This arrangement is ideal in reducing the number of seeded cells.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Prime is from Apollo (Gen 1) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Ideal for cell cultures

HD-MEA Prime

Prime is a high-density microelectrode array integrating 4,096 recording electrodes on a small and compact area of 2.67 mm x 2.67 mm, centered on a flat area of ~3 mm x 3 mm. This arrangement is ideal in reducing the number of seeded cells.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Prime is from Apollo (Gen 1) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Ideal for cell cultures

HD-MEA Prime

Prime is a high-density microelectrode array integrating 4,096 recording electrodes on a small and compact area of 2.67 mm x 2.67 mm, centered on a flat area of ~3 mm x 3 mm. This arrangement is ideal in reducing the number of seeded cells.

Each microelectrode is 21 µm x 21 µm, with a 42 µm pitch. The internal diameter of the reservoir is 25 mm, with a height of 7 mm.

HD-MEA Prime is from Apollo (Gen 1) chipset family and can be used with BioCAM X and BioCAM DupleX.

At a glance

Tech specs

HD-MEA Accura

Main Electrode Array

Mode of operation

Recording and stimulation

# of electrodes

4096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

3.84 mm x 3.84 mm

Electrode size

21 µm x 21 µm

Electrode pitch

60 µm

Working Area

Flat area size

~6 mm x 6 mm

HD-MEA Arena

Main Electrode Array

Mode of operation

Recording

# of electrodes

4096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

2.67 mm x 2.67 mm

Electrode size

21 µm x 21 µm

Electrode pitch

42 µm

Working Area

Flat area size

~6 mm x 6 mm

HD-MEA Stimulo

Main Electrode Array

Mode of operation

Recording

# of electrodes

4096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

5.12 mm x 5.12 mm

Electrode size

21 µm x 21 µm

Electrode pitch

81 µm

Second Electrode Array

Mode of operation

Stimulation

# of electrodes

16 arranged in a 4 x 4 grid and uniformly interspersed between main array

Electrodes' area size (active area)

3.96 mm x 3.96 mm

Electrode size

21 µm x 21 µm

Electrode pitch

1.3 mm

Working Area

flat area size

~6 mm x 6 mm

HD-MEA Prime

Main Electrode Array

Mode of operation

Recording

# of electrodes

4096 arranged in a 64 x 64 grid

Electrodes' area size (active area)

2.67 mm x 2.67 mm

Electrode size

21 µm x 21 µm

Electrode pitch

42 µm

Working Area

Flat area size

~3 mm x 3 mm

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