dissociated cultures

Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Chargepaper

ACS Nano, DOI:10.1021/acsnano.7b00397

Dante S., Petrelli A., Petrini E., Marotta E., Maccione A., Alabastri A., Quarta A., De Donato F., Ravasenga T., Sathya A., Cingolani R., Proietti Zaccaria R., Berdondini L., Barberis A., Pellegrino T.

dissociated cultures

High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studiespaper

Scientific Reports 7, Article number: 2460 (2017) doi:10.1038/s41598-017-02635-x

Amin H., Nieus T., Lonardoni D., Maccione A. and Berdondini L.

dissociated cultures

Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for three-month culture with 4096-electrode arrayspaper

Front. Neurosci., 2016 , doi: 10.3389/fnins.2016.00121.

Amin H., Maccione A., Marinaro F., Zordan S., Nieus T., Berdondini L.

dissociated cultures

Propagation and synchronization of reverberatory bursts in developing cultured networkspaper

J Comput Neurosci (2016). doi:10.1007/s10827-016-0634-4.

Huang CH., Huang YT., Chen CC., Chan CK.

dissociated cultures

State-Dependent Propagation of Neuronal Sub-Population in Spontaneous Synchronized Burstspaper

Front. Syst. Neurosci., 2016 , doi: 10.3389/fnsys.2016.00028.

Yuichiro Y., Ryohei K. and Hirokazu T.

dissociated cultures

High-density MEA recordings unveil the dynamics of bursting events in Cell Culturesconf. proc.

Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE. doi:10.1109/EMBC.2015.7319212.

Lonardoni D., Di Marco S., Amin H., Maccione A., Berdondini L., Nieus T.

dissociated cultures

Investigating cell culture dynamics combining high density recordings with dimensional reduction techniquesconf. proc.

Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE. doi:10.1109/EMBC.2015.7319211.

Nieus T. , Di Marco S. , Maccione A. , Amin H. , Berdondini L.

dissociated cultures

Sloppiness in Spontaneously Active Neuronal Networkspaper

Journal of Neuroscience 3 June 2015, 35(22): 8480-8492; doi: 10.1523/JNEUROSCI.4421-14.2015.

Panas D., Amin H., Maccione A., Muthmann O., van Rossum M., Berdondini L. and Hennig M.

dissociated cultures

Functional Connectivity Estimation over Large Networks at Cellular Resolution based on Electrophysiological Recordings and Structural Priorpaper

Frontiers in Neuroanatomy (2014), doi: 10.3389/fnana.2014.00137.

Ullo S. , Nieus T. , Sona D. , Maccione A. , Berdondini L. and Murino V.

dissociated cultures

Alzheimer's disease (AD) in-vitro model: a novel drug screening approach on 4096-microelectrode recording arraysconf. proc.

9th FENS Meeting July 5-9, Milano (2014).

Amin H., Maccione A., Nieus T., Berdondini L.

dissociated cultures

Differentiation and functional integration of adult-born hippocampal neurons: a study on high-resolution microelectrode arrays (MEA)conf. proc.

9th FENS Meeting July 5-9, Milano (2014).

Simi A., Maccione A., Nieus T., De Pietri Tonelli D., Berdondini L.

dissociated cultures

High resolution microelectrode arrays (MEAs) for reliably studying an in-vitro neuronal network model of induced-Alzheimer's diseaseconf. proc.

Biosensors 2014 May 27-30, Melbourne (2014).

Amin H., Maccione A., Nieus T., Berdondini L.

dissociated cultures

Investigating the interplay between intrinsic and evoked activities in cultured neuronal networks by dimensional reduction techniques and high-density MEAsconf. proc.

CNS Meeting 2013 - BMC Neuroscience 2013, 14 (Suppl 1):P24 doi:10.1186/1471-2202-14-S1-P24.

Nieus T., Maccione A. and Berdondini L.

dissociated cultures

Neuronal network structural connectivity estimation by probabilistic features and graph heat kernelsconf. proc.

International Symposium on BIOMEDICAL IMAGING: From Nano to Macro, San Francisco (2013).

Ullo S., Castellani U., Sona D., Del Bue A., Maccione A., Berdondini L., Murino V.

dissociated cultures

Multi-site electrical stimulation integrated on 4096 high density micro electrode arrays (MEAs) reveals the effective connectivity of dissociated neuronal culturesconf. proc.

SFN Conference, October 13-17, New Orleans (2012).

Maccione A., Nieus T., Simi A., Amin H. and Berdondini L.

dissociated cultures

Structural and functional identification of sub-networks in dissociated neuronal cultures: an automated multimodal analysis combining high density MEA and fluorescence imagingconf. proc.

MEA meeting, July 10-13, Reutlingen, Germany (2012).

Maccione A., Ullo S., Simi A., Nieus T., Sona D., Del Bue A., Murino V. and Berdondini L.

dissociated cultures

Multiscale functional connectivity estimation on low density neuronal cultures recorded by high density CMOS Micro Electrode Arrayspaper

Journal of Neuroscience Methods, Vol 207, Issue 2 (2012) doi:10.1016/j.jneumeth.2012.04.002.

Maccione A., Garofalo M., Nieus T., Tedesco M., Berdondini L. and Martinoia S.

dissociated cultures

A comparison between low- and high-density analyses on 2D neuronal networks by means of high resolution CMOS-MEAsconf. proc.

SfN Conference 2010.

Maccione A., Gandolfo M., Tedesco M., Imfeld K., Martinoia S., and Berdondini L.

dissociated cultures

Tracking burst patterns in hippocampal cultures with high-density CMOS-MEAs. (paper)paper

J. Neural Eng. 7 (2010), doi:10.1088/1741-2560/7/5/056001.

Gandolfo M., Maccione A., Tedesco M., Martinoia S., and Berdondini L.

dissociated cultures

Functional connectivity maps in hippocampal cultures coupled to high resolutions MEAs underlie structural connectivityconf. proc.

MEA meeting 2010 Reutlingen, Germany.

Maccione A., Garofalo M., Nieus T., Tedesco M., Commisso E., Martinoia S., and Berdondini L.

dissociated cultures

Experimental investigation on spontaneously active hippocampal cultures recorded by means of high-density MEAs: analysis of the spatial resolution effectspaper

Frontiers in Neuroengineering (2010), doi:10.3389/fneng.2010.00004.

Maccione A., Gandolfo M., Tedesco M., Nieus T., Imfeld K., Martinoia S., and Berdondini L. 

dissociated cultures

Active pixel sensor array for high spatio-temporal resolution electrophysiological recordings from single cell to large scale neuronal networkspaper

Lab on a Chip 9 (2009), pp. 2644-2651.

Berdondini L., Imfeld K., Maccione A., Tedesco M., Neukom S., Koudelka-Hep M., and Martinoia S. 

acute brain slices

Exploiting high content datasets recorded with high density Multi Electrode Array to investigate compounds functional effects with LTP protocols in cortico-hippocampal brain slicesconf. proc.

SFN conference 2016

Zordan S., Ugolini A., Virginio C., Corsi M., Lonardoni D., Gandolfo M., Maccione A. and Berdondini L.

acute brain slices

Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mousepaper

Cerebral Cortex (2014), doi: 10.1093/cercor/bhu141

Medrihan L., Ferrea E., Greco B., Baldelli P. and Benfenati F.

acute brain slices

Can a pro-seizures effect be predicted? Evaluation of two technological approaches in hippocampal slicesconf. proc.

Safety Pharmacology Society Meeting, 16-19 september 2013 Rotterdam.

Ugolini A., Maccione A., Gandolfo M., Corsi M., Virginio C.

acute brain slices

Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizurespaper

Front Cell Neurosci. 2013; 7: 138. doi: 10.3389/fncel.2013.00138.

Toader O., Forte N., Orlando M., Ferrea E., Raimondi A., Baldelli P., Benfenati F. and Medrihan L.

acute brain slices

Large-scale, high resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrayspaper

Frontiers in Neural Circuits, Vol 6 Article 80 (2012) doi:10.3389/fncir.2012.00080.

Ferrea E., Maccione A., Medrihan L., Nieus T., Ghezzi D., Baldelli P., Benfenati F. and Berdondini L.

acute brain slices

Investigation of the spatio-temporal propagation pattern of epileptic events in cortico-hippocampal slices by means of high-density CMOS micro electrode arrays.conf. proc.

SfN Conference 2010.

Ferrea E., Medrihan L., Maccione A., Baldelli P., Benfenati F., and Berdondini L.

acute brain slices

Effect of tonic inhibition on epileptiform activity in synapsin II KO miceconf. proc.

FENS Conference 2010

Medrihan L., Ferrea E., Maccione A., Bernondini L., Benfenati F., and Baldelli P.

acute brain slices

Electrophysiological imaging of epileptic brain slices reveals pharmacologically confined functional changesconf. proc.

MEA meeting, July 10-13, Reutlingen, Germany (2012).

Ferrea E., Medrihan L., Ghezzi D., Nieus T., Baldelli P., Benfenati F. and Maccione A.

acute retina

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retinapaper

Sci Rep. 2017; 7: 42330. doi:  10.1038/srep42330

Hilgen G., Pirmoradian S., Pamplona D., Kornprobst P., Cessac B., Hennig M., Sernagor E.

acute retina

Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responsespaper

Sci Rep. doi:10.1038/srep33565

Barrett J. M., Hilgen G. and Sernagor E.

acute retina

Rank order coding: a retinal information decoding strategy revealed by large-scale multielectrode array retinal recordings.paper

ENeuro doi: 10.1523/ENEURO.0134-15.2016.

Portelli G., Barrett J.M., Hilgen G., Masquelier T., Maccione A., Di Marco S., Berdondini L., Kornprobst P., Sernagor E.

acute retina

A high-resolution experimental platform for large-scale recording of light-evoked responses in the retinal ganglion cell layerconf. proc.

FENS Conference 2014

Di Marco S., Maccione A., Nieus T., Hennig M., Pirmoradian S., Hilgen G., Sernagor E., Berdondini L.

acute retina

High Resolution Large-Scale Recordings of Light Responses from Mouse Retinal Ganglion Cellsconf. proc.

MEA meeting 2014 Reutlingen, Germany.

Hilgen G., Maccione A., Di Marco S., Berdondini L., Sernagor E.

acute retina

Following the Ontogeny of Retinal Waves: Pan-Retinal Recordings of Population Dynamics in the Neonatal Mousepaper

The Journal of Physiology - doi: 10.1113/jphysiol.2013.262840.

Maccione A., Hennig M., Gandolfo M., Muthmann O., van Coppenhagen J., Eglen S. J., Berdondini L. and Sernagor E.

acute retina

Mapping large scale retinal population activity with high density multielectrode arraysconf. proc.

Cosyne Meeting 2014, Salt Lake City, UT, USA

Pirmoradian S., Hilgen G., Muthman O., Maccione A., Bhalla U., Berdondini L., Sernagor E., Hennig M.H.

acute retina

Deciphering Retinal Functional Circuitry: High Resolution Large-Scale Population Recordings From The Mouse Retinal Ganglion Cell Layerconf. proc.

European Retina Meeting ERM - October 2 - 5, 2013 Alicante, Spain

Sernagor E., Hilgen G., Barrett J., Hennig M., Maccione A., Berdondini L.

acute retina

Analysis of simultaneous multielectrode recordings with 4096 channels: changing dynamics of spontaneous activity in the developing retinaconf. proc.

CNS meeting, July 23-28, Sweden (2011).

Hennig M., Maccione A., Gandolfo M., Down M., Eglen S. J., Berdondini L. and Sernagor E.

acute retina

Changing dynamics of spontaneous waves during retinal development: a novel panretinal perspective achieved with the active pixel sensor (APS) 4096 electrodes arrayconf. proc.

SFN meeting 2010

Sernagor E., Maccione A., Hennig M., Gandolfo M., Eglen S., and Berdondini L.

cardiomyocyte

Large-scale, high-resolution data acquisition system for extracellular recording of electrophysiological activity.paper

IEEE Trans Biomed Eng. 2008 Aug;55(8):2064-73. doi: 10.1109/TBME.2008.919139.

Imfeld K., Neukom S., Maccione A., Bornat Y., Martinoia S., Farine PA., Koudelka-Hep M., Berdondini L.

technology

Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networkspaper

Lonardoni D., Hayder A., Di Marco S., Maccione A., Berdondini L., Nieus T.

technology

Specific Neuron Placement on Gold and Silicon Nitride-Patterned Substrates through a Two-Step Functionalization Methodpaper

Langmuir (2016). doi:10.1021/acs.langmuir.6b01352.

Mescola A., Canale C., Prato M., Diaspro A., Berdondini L., Maccione A., and Dante S.

technology

Microelectronics, bioinformatics and neurocomputation for massive neuronal recordings in brain circuits with large scale multielectrode array probespaper

Brain Research Bulletin, https://doi.org/10.1016/j.brainresbull.2015.07.008

Maccione A., Gandolfo M., Zordan S., Amin H., Di Marco S., Nieus T., Angotzi G.N., Berdondini L.

technology

Large-Scale recording of light-evoked responses in the retinal ganglion cell layer of the explanted retina: A new HD experimental platformconf. proc.

SFN November 15-19 Washington, DC US (2014).

Di Marco S., Maccione A., Hilgen G., Pirmoradian S., Nieus T., Hennig M., Sernagor E., Berdondini L.

technology

Structured neuronal networks investigated by high-resolution MEAsconf. proc.

FENS Forum, July 14-18, Barcellona (2012)

Simi A., Bosca A., Maccione A., Nieus T., Brandi F., Dante S. and Berdondini L.

technology

3D plasmonic hollow nanoantennas as tools for neuroscience applicationsconf. proc.

CLEO: Science and Innovations San Jose, California United States June 8-13, 2014 ISBN: 978-1-55752-999-2

Dipalo M., Malerba M., Messina G. C., La Rocca R., Amin H., Maccione A., Berdondini L., De Angelis F.

technology

3D plasmonic nanoelectrodes for intracellular recording of large-scale neuronal networksconf. proc.

EMRS spring meeting, May 26-30 Lille France (2014)

Dipalo M., Malerba M., Simi A., Amin H., Maccione A., Berdondini L., De Angelis F.

technology

Micro-/Nano-Technologies and Microelectronics for Neuroscience Research and Applicationsconf. proc.

6th European Conference of the International Federation for Medical and Biological Engineering IFMBE Proceedings Volume 45, 2015, pp 781-784 (2014)

Simi A., Amin H., Maccione A., Nieus T., Di Marco S., Dipalo M., Talaei S., Koudelka-Hep M., van der Wal P. D., de Rooij N. F., Berdondini L.

technology

Novel 3D plasmonic nano-electrodes for cellular investigations and neural interfacesconf. proc.

SPIE 9166, Biosensing and Nanomedicine VII, 27 August 2014, doi: 10.1117/12.2066274 (2014)

Malerba M., Dipalo M., Messina G. C., Amin H., La Rocca R., Shalabaeva V., Simi A., Maccione A., Berdondini L.

technology

Integration of microstructured scaffolds, neurons, and multielectrode arraysbook chapter

“Brain Extracellular Matrix in Health and Disease” Ed. Dityatev, Wehrle-Haller and Pitkänen, Elsevier 1st Edition (2014) doi:10.1016/B978-0-444-63486-3.00017-7

Simi A., Amin H., Maccione A., Nieus T., Berdondini L.

technology

Brain Function: Novel Technologies Driving Novel Understandingbook chapter

Bioinspired Approaches for Human-Centric Technologies, Cingolani, Roberto (Ed.), 2014 (p. 299 and following)

Assad J. A. , Berdondini L. , Cancedda L. , De Angelis F. , Diaspro A. , Dipalo M. , Fellin T. , Maccione A., Panzeri S. and Sileo L.

technology

Active Pixel Sensor Multielectrode Array for High Spatiotemporal Resolutionbook chapter

Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing 2014, pp 207-238

Berdondini L., Bosca A. , Nieus T., Maccione A.

technology

Electrical Coupling of Mammalian Neurons to Microelectrodes with 3D Nanoprotrusionspaper

Microelectronic Engineering Volume 111, (2013), Pages 384-390

Sileo L., Pisanello F., Quarta L., Maccione A., Simi A., Berdondini L., De Vittorio M., Martiradonna L.

technology

Sensing and actuating electrophysiological activity on brain tissue and neuronal cultures with a high-density CMOS-MEAconf. proc.

IEEE conference 2013

Maccione A., Simi A., Nieus T., Gandolfo M., Imfeld K., Ferrea E., Sernagor E., and Berdondini L.

technology

Beam induced deposition of 3D electrodes to improve coupling to cellspaper

Microelectronic Engineering, ISSN 0167-9317 (2012) doi:10.1016/j.mee.2012.03.027.

Martiradonna L., Quarta L., Sileo L., Schertel A., Maccione A., Simi A., Dante A., Scarpellini A., Berdondini L. and De Vittorio M.

technology

Investigating 2D/3D patterned networks coupled with high-resolution MEAs for functional studiesconf. proc.

CNS Meeting

Hennig M. H., Maccione A., Gandolfo M., Down M., Eglen S. J., Berdondini L. and Sernagor E.

technology

Coupling neuronal cultures grown on flexible laser-etched porous membranes with CMOS-MEAconf. proc.

The 6th International Conference on Microtechnologies in Medicine and Biology (MMB 2011)

Marconi E., Maccione A., Simi A., Bosca A., Brandi F., Benfenati F., Dante S. and Berdondini L.

technology

Recording retinal waves with a 4096 electrodes array: novel analytical and data sharing toolsconf. proc.

INCF conference 2010

Sernagor E., Maccione A., Gandolfo M., Eglen S., Hennig M., and Berdondini L.

technology

Active Pixel Sensor Micro Electrode Arrays (APS-MEA): perspectives and challenges using a high resolution neuroelectronic interface for functional electrophysiological imaging of in-vitro neuronal netconf. proc.

SFN meeting 2009

Maccione A., Gandolfo M., Imfeld K., Tedesco M., Ferrea E., Martinoia S., and Berdondini L.

signal processing

Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrayspaper

Cell Reports DOI: http://dx.doi.org/10.1016/j.celrep.2017.02.038

Hilgen G., Sorbaro M, Pirmoradian S, Muthmann J-O., Kepiro I, Ullo S., Rmairez C. J., Encinas A. P., Maccione A., Berdondini L., Murino V., Sona D., Cella Zanacchi F., Sernagor E., Hennig M. type

signal processing

ToolConnect: a functional connectivity toolbox for in vitro networkspaper

Frontiers in Neuroinformatics (2016), doi: 10.3389/fninf.2016.00013

Pastore V. P., Poli D., Godjoski A., Martinoia S., Massobrio P. type

signal processing

Spike detection for large neural populations using high density multielectrode arrayspaper

Frontiers in Neuroinformatics (2015), vol. 9, ISSN:1662-5196 DOI:10.3389/fninf.2015.00028

Muthmann O., Amin H., Sernagor E., Maccione A., Panas D., Berdondini L., Bhalla U. S., Hennig M. type

signal processing

Characterizing neural population response with high-density multielectrode arraysconf. proc.

SFN conference 2014

Pirmoradian S., Hilgen G., Muthmann O., Maccione A., Bhalla U., Berdondini L., Sernagor E., Hennig M. H. type

signal processing

A computational model of hippocampal neuronal networks: the role of connectivity in the appearance of synchronized bursting eventsconf. proc.

EMRS spring meeting

Lonardoni D., Berdondini L., Nieus T. type

signal processing

Estimating the fraction of falsely detected spikes in high density microelectrode array recordings based on correlationsconf. proc.

NCBS 38th Annual National Conference

Muthmann J-O., Amin H., Maccione A., Sernagor E., Berdondini L., Hennig M. and Bhalla U.S. type

signal processing

Tools for analysis of high-density multielectrode recordings in the neonatal mouse retinaconf. proc.

Front. Neuroinform 2013. Conference Abstract: 5th INCF Congress of Neuroinformatics. doi: 10.3389/conf.fninf.2013.08.00004

Hennig M., Muthmann O., Maccione A., Gandolfo M., Eglen S., Berdondini L. and Sernagor E. type

signal processing

Investigating the interplay between intrinsic and evoked activities in cultured neuronal networks by dimensional reduction techniques and high-density MEAsconf. proc.

BMC Neuroscience 2013, 14(Suppl 1):P24 doi:10.1186/1471-2202-14-S1-P24

Nieus T., Maccione A., Berdondini L. type

signal processing

Estimating the fraction of falsely detected spikes in high density microelectrode array recordings based on correlationsconf. proc.

CNS Meeting 2013 - BMC Neuroscience 2013

Muthmann J-O., Amin H., Maccione A., Sernagor E., Berdondini L., Hennig M. and Bhalla U.S. type

signal processing

Homeostasis in large networks of neurons through the Ising model - do higher order interactions matter?conf. proc.

CNS Meeting 2013 - BMC Neuroscience 2013

Panas D., Maccione A., Berdondini L. and Hennig M. type

signal processing

Estimating Electrical Conductivity Tensors of Biological Tissues Using Microelectrode Arrayspaper

Ann Biomed Eng (2012) doi: 10.1007/s10439-012-0581-9.

Gilboa E., La Rosa P.S. and Nehorai A.  type

signal processing

A joint structural and functional analysis of in-vitro neuronal networksconf. proc.

International Conference on Image Processing

Ullo S., Del Bue A., Maccione A., Berdondini L. and Murino V. type

signal processing

Towards tracking homeostatic changes on high-density multielectrode arraysconf. proc.

Bernstein Conference

Panas D., Maccione A., Berdondini L. and Hennig M. type

signal processing

What can MaxEnt reveal about high-density recordings and what can high-density recordings reveal about MaxEnt?conf. proc.

CNS meeting

Dagmara P., Maccione A., Berdondini L., and Hennig M. type

signal processing

Active Pixel Sensor Micro Electrode Array (APS-MEA): analysis of the network dynamics from hippocampal neuronal populations recorded at high spatio-temporal resolutionconf. proc.

SFN meeting 2009

Gandolfo M., Imfeld K., Tedesco M., Maccione A., Berdondini L., and Martinoia S. type

signal processing

A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signalspaper

Journal of Neuroscience Methods, 177, 241-249, 2009

Maccione A., Gandolfo M., Massobrio P., Novellino A., Martinoia S., Chiappalone M. type

signal processing

Real-time signal processing for high-density microelectrode array systemspaper

Int. J. Adapt. Control Signal Process. 2009; 23: 983-998

Imfeld K., Maccione A., Gandolfo M., Martinoia S., Farine P.-A., Koudleka-Hep M. and Berdondini L. type