Retina and further applications

Discover how high-resolution functional imaging can help in studying the processing pathways of the retina and explore other applications

Overview

Retina

Explanted retinas from different animal models (e.g. murine, salamander, primates etc...) can be studied up-close with the active microelectrode area of our high-density microelectrode array, also known as multielectrode array (HD-MEA), platforms. Record spontaneous or light-induced electrophysiological activity generated by the retinal ganglion cell layer and run sophisticated analyses like spike-detection to evaluate your results for statistical significance. See more

Our high-resolution HD-MEA technology allows researchers to:

  • Map the activity of the entire retinal ganglion cell layer at single-cell resolution. See more videos

  • Record light-induced network activity by combining our BioCAM X with light-stimulation devices. See all videos
The spatial extent (from 7.1 mm2 up to 26.2 mm2) of the HD-MEA allows to record from large retinal areas simultaneously. Adapted from G. Hilgen et al., Sci. Rep. 2017. See more

Optogenetics

Our HD-MEA can also be combined with optogenetic stimulation tools for spatiotemporally precise excitation/inhibition of cells, as seen in the side image, where optogenetics was successfully used in a study on retinitis pigmentosa. See more

High resolution imaging can be used to assess light sensitivity by using sophisticated stimuli inspired by those used in clinical visual assessment. Adapted from J.M. Barrett et al., Sci. Rep. 2016. See more

To discuss further research possibilities and applications, please contact us.