CorePlate™ 6W: Multiple cores for cell-based assays without compromises

Name: CorePlate™ 6W
Brand: 3Brain AG
Availability: InStock

After being the first introducing CMOS-based HD-MEA (in 2011) to overcome passive MEA limitations, we are now setting up the next standard setting up the next standard by introducing the CorePlate™ technology, a multi-well plate HD-MEA with integrated processing power.

Overview

Your partner in drug discovery

Drug discovery, efficacy testing and toxicological screening require readout parallelization over multiple samples to account for biological variability but also to accelerate time-to-results.

This increased throughput is often achieved at the cost of a reduction in the number of sensed cells, thus making the assay less predictive and requiring more repetitions of the same experiments.

CorePlate™ 6W 38/60 enables the simultaneous measurement of thousands of neurons per well, thus increasing the statistical significance of your experiments.

Elaborate network analyses at single-cell resolution and simultaneously over the multi-well plate are made possible in preparations such as brain slices, neuronal tissue, human iPSC-derived neuronal networks, brain organoids, spheroids and cardiac cultures.

At a glance

Obtain More Data from Your Organoids, Spheroids, and Brain Slices

CorePlate™ 6W-3D 38/60/90

CorePlate™ 6W-3D 38/60/90 integrates 4 096 bidirectional electrodes per well arranged in maximum seeding area of approx. 40 mm². Up to 2 304 electrodes at 10 kHz or 1 024 electrodes at 20 kHz can be simultaneously recorded per well by selecting a subset of the 4 096-electrode array, allowing you to either maximize the recorded area or the spatial resolution.

Each 14 µm × 14 µm electrode is elevated on a 90 µm-high biocompatible insulated micropillar. This allows the electrodes to gently penetrate into the sample, significantly improving the amount of data obtained without damaging the samples themselves.

At the base of every micropillar, a pedestal structure enables passive microfluidic flow, enhancing oxygenation and promoting more uniform distribution of compounds and drugs throughout the sample.

All 4,096 electrodes are fully bidirectional, allowing researchers to record and perform targeted electrical stimulation.

The culture reservoir, with an internal diameter of 33.5 mm and a height of 16 mm, accommodates a wide range of organoid, spheroid, and brain slice preparations.

CorePlate™ 6W -3D 38/60/90 is compatible with the HyperCAM Alpha.

Flexible layout for both cell cultures and brain tissues

CorePlate™ 6W 38/60

CorePlate™ 6W 38/60 integrates 4 096 bidirectional electrodes per well arranged in maximum seeding area of approx. 40 mm². Up to 2 304 electrodes at 10 kHz or 1 024 electrodes at 20 kHz can be simultaneously recorded per well by selecting a subset of the 4 096-electrode array. Different recording subsets are available to either maximize the recorded area or the spatial resolution, and to suit both cell cultures and brain tissues.

Moreover, each of the 4 096 electrodes are bidirectional and can be used to release an electrical stimulation to your sample.

Each microelectrode is 30 µm × 30 µm, with a 60 µm pitch. The internal diameter of the well reservoir is 33.5 mm, with a height of 16 mm.

CorePlate™ 6W 38/60 is compatible with the HyperCAM Alpha.

At a glance

Tech specifications

CorePlate™ 6W-3D 38/60/90

Primary Array

Mode of operation

Recording and stimulation (bidirectional)

Number of electrodes

4 096 per well, 64 × 64 grid (24 576 per plate)

Number of stimulating electrodes

4 096 per well (24 576 per plate)

Electrode size

Pedestal: approx. 34 µm × 34 µm × 20 µm (W × D × H)
Pillar: approx. 14 µm × 14 µm × 90 µm (W × D × H) 3

Electrode material

Au with parylene insulation

Configuration 1

Number of electrodes

2 304 arranged in a 48 × 48 grid (13 824 per plate)

Electrode pitch

60 µm

Electrode array dimensions (sensed area)

2.85 mm × 2.85 mm

Configuration 2

Number of electrodes

1 024 arranged in a 32 × 32 grid (6 144 per plate)

Electrode pitch

60 µm

lectrode array dimensions (sensed area)

1.89 mm × 1.89 mm

Configuration 3

Number of electrodes

1 024 arranged in a 32 × 32 grid (6 144 per plate)

Electrode pitch

120 µm

lectrode array dimensions (sensed area)

3.75 mm × 3.75 mm

Physical specifications

Exposed chip area (maximum seeding area)

~ 40 mm²

Well internal opening dimension

Ø 33.5 mm

Maximum well volume

12.7 mL

Maximum internal depth

16.0 mm

Size (W × D × H)

127.8 mm × 85.5 mm × 19.0 mm
5.03 in × 3.37 in × 0.75 in

CorePlate™ 6W 38/60

Primary Array

Mode of operation

Recording and stimulation (bidirectional)

Number of electrodes

4 096 per well, 64 × 64 grid (24 576 per plate)

Number of stimulating electrodes

4 096 per well (24 576 per plate)

Electrode size

30 µm × 30 µm

Electrode material

Configuration 1

Number of electrodes

2 304 arranged in a 48 × 48 grid (13 824 per plate)

Electrode pitch

60 µm

Electrode array dimensions (sensed area)

2.85 mm × 2.85 mm

Configuration 2

Number of electrodes

1 024 arranged in a 32 × 32 grid (6 144 per plate)

Electrode pitch

60 µm

lectrode array dimensions (sensed area)

1.89 mm × 1.89 mm

Configuration 3

Number of electrodes

1 024 arranged in a 32 × 32 grid (6 144 per plate)

Electrode pitch

120 µm

lectrode array dimensions (sensed area)

3.75 mm × 3.75 mm

Physical specifications

Exposed chip area (maximum seeding area)

~ 40 mm²

Well internal opening dimension

Ø 33.5 mm

Maximum well volume

12.7 mL

Maximum internal depth

16.0 mm

Size (W × D × H)

127.8 mm × 85.5 mm × 19.0 mm
5.03 in × 3.37 in × 0.75 in

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CorePlate™ 6W: Multiple cores for cell-based assays without compromises

Overview

Your partner in drug discovery

At a glance

Obtain More Data from Your Organoids, Spheroids, and Brain Slices

CorePlate™ 6W-3D 38/60/90

Flexible layout for both cell cultures and brain tissues

CorePlate™ 6W 38/60

At a glance

Tech specifications

CorePlate™ 6W-3D 38/60/90

Primary Array

Configuration 1

Configuration 2

Configuration 3

Physical specifications

CorePlate™ 6W 38/60

Primary Array

Configuration 1

Configuration 2

Configuration 3

Physical specifications

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