Introducing a fully bi-directional microelectrode array platform for 2D and 3D in vitro electrophysiology
BioCAM DupleX is a state-of-the-art microelectrode array, also known as a multielectrode array (MEA), platform for powerful in vitro functional imaging.
Its bidirectional capabilities allow researchers to simultaneously record high-density electrophysiological data at 18kHz and induce electrical stimulation at any of the 4,096 microelectrodes.
In addition to this micrometer-precise electrical stimulation, active and passive light shielding allow the use of optogenetic tools without affecting chip functionality.
This advanced platform works with both classical planar as well as innovative 3D CMOS MEA technology.
The BioCAM DupleX will utilize our latest generation of Khíron chips, which feature 4,096 µNeedle electrodes to penetrate structured brain tissues like slices, organoids, spheroids and obtain signals from inside your biological models, thus dramatically increasing the quality of your data samples.
The BioCAM DupleX is the first MEA plaftorm of its kind, able to power 3D high-density CMOS-MEA chips.
With the Khíron ASIC family developed by 3Brain, the BioCAM DupleX can simultaneously record and stimulate from all 4,096 microelectrodes structured in the penetrating µNeedle grid.
These revolutionary µNeedle electrodes access information inside all kinds of tissues like slices, organoids, spheroids and scaffolded 3D cultures without damaging them, making the BioCAM DupleX the only platform for in-tissue 3D functional imaging.
After inserting a microelectrode array (MEA) chip into the BioCAM DupleX, the motorized locking mechanism activates with a simple press of the lock button to enable precise contact aligment. The system automatically recognizes the MEA chip and is ready to acquire data.
Advanced FPGA control to denoise, filter and compress high-density data
All the surfaces around the MEA chip are magnetic for easy setup with other equipment, such as perfusion holders
Integrated heating and cooling system
2 independently programmable stimulator channels (1 voltage and 1 current)
A motorized solution to reliably lock and unlock your microelectrode array (MEA) chips
Crafted from aluminium to shield from electromagnetic and mechanical noise
Here at 3Brain, we pay attention to each and every detail because we know how much they count in the success of your experiments.
From the intricate electronic ciruitry and the mechanics of the device to the state-of-art material chosen for the case and the optimized user interface, even down to the product packaging, everything has been designed to give you a unique experience and to help you concentrate on what matters most: your results.
|Computational core||Intel®'s Arria® 10 FPGA 13Gbps, 2GB DDR4, and ARM® dual-core Cortex™-A9 1.5 GHz|
|Data resolution||12 bit|
|Number of simultaneous recording channels||4096|
|Sampling frequency (full-array)||20 kHz/electrode|
|Region-of-interest||1 - 4 independent subsets of electrodes (up to 64kHz sampling frequency)|
|Temperature control||Active heating and cooling system|
|Data interface||USB 3.1 Type-C|
|Ground reference||On-chip integrated|
|HD-MEA compatibility||Prime, Arena, Stimulo, Accura|
|3D HD-MEA compatibility||Accura 3D (firmware upgrade required)|
|Control software compatibility||BrainWave 4 or higher|
|Inputs||Two analog inputs (-3.3 V to 3.3 V) or triggers (LV-TTL)|
|Integrated stimulation module||Yes|
|Real-time stimulation controller||Yes|
|Internal (on-chip) stimulation sites||4096 (only with HD-MEA Accura)|
|External stimulation sites||4 differential channels (accessible with optional connector box)|
|Current stimulus generator||Yes|
|Number of channels||1 (only for external stimulation sites)|
|Maximum amplitude||+/- 1 mA|
|Amplitude resolution||10 µA|
|Time resolution||10 µs|
|Voltage stimulus generator||Yes|
|Number of channels||1 (only for internal stimulation sites)|
|Maximum amplitude||10 V (peak-to-peak)|
|Amplitude resolution||200 µV|
|Time resolution||10 µs|
|Body material||Anodized aluminum and stainless steel|
|Protection from liquid spill over||Anti spill barrier v. 2|
|Dimensions (W x D x H)||180 x 230 x 42 mm / 7.09 x 9.05 x 1.65 inches|
|Weight||2 Kg / 4.4 pounds|