Where the functional screening revolution begins

Introducing a fully bi-directional microelectrode array platform for 2D and 3D in vitro imaging

Overview

In vitro electrophysiology reimagined

BioCAM DupleX is a state-of-the-art, high-resolution microelectrode array (also known as multielectrode array) platform for powerful in vitro functional imaging.

Its bidirectional electrodes make it possible to simultaneously record high-density electrophysiological data at 20 kHz and induce electrical neural network stimulation from any of the 4,096 microelectrodes.

This advanced platform works with both classical planar 2D cell culture as well as our innovative 3D HD-MEA technology.
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The BioCAM DupleX is compatible with our latest generation of Khíron chips, which feature 4,096 µNeedle electrodes to penetrate structured brain tissues and obtain signals from inside your biological models such as slices, organoids, or spheroids.

Our journey to perfection

1 product, 15 years of R&D

BioCAM DupleX is the result of 15 years of research and development, embodying our experience in bioengineering CMOS microelectrode array (MEA) devices, electrophysiology, data processing and biological models.
It is electrophysiology at its best.

BioCAM Idea
2004

BioCAM 4096
2012

BioCAM X
2015

BioCAM DupleX
2019

Electrophysiology in 3D

An ideal match: BioCAM DupleX and Khíron

The BioCAM DupleX is the first Microelectrode Array platform of its kind able to power 3D high-density CMOS-MEA chips.

With the Khíron microchip family developed by 3Brain, the BioCAM DupleX can simultaneously record and stimulate from all 4,096 microelectrodes structured in a penetrating µNeedle grid.

These revolutionary µNeedle electrodes access information from inside all kinds of tissues – such as slices, organoids, spheroids and scaffolded 3D cultures – without damaging them, making the BioCAM DupleX the only platform for high-resolution in vitro 3D functional imaging.

Electrophysiology in 3D

An ideal match: BioCAM DupleX and Khíron

The BioCAM DupleX is the first MEA plaftorm of its kind, able to power 3D high-density CMOS-MEA chips.

With the Khíron ASIC family developed by 3Brain, the BioCAM DupleX can simultaneously record and stimulate from all 4,096 microelectrodes structured in the penetrating µNeedle grid.

These revolutionary µNeedle electrodes access information inside all kinds of tissues like slices, organoids, spheroids and scaffolded 3D cultures without damaging them, making the BioCAM DupleX the only platform for in-tissue 3D functional imaging.

Electrophysiology revolutionized

Complex electrophysiology setups, where the wiring of a single electrode to the amplifier can significantly change the noise level and impair the experiment, or where the interpretation of the signals coming from your setup is restricted to electrophysiological experts, are now a distant memory.

BioCAM DupleX makes setup as easy as possible by automating important settings and optimizing noise, thus making electrophysiology accessible to everyone. Complex electrophysiological traces are then converted into microscopy-like, easy-to-understand, fast-to-process functional images.

BioCAM DupleX makes setup as easy as possible by automating important settings and optimizing noise, thus making electrophysiology accessible to everyone. Complex electrophysiological traces are then converted into microscopy-like, easy-to-understand, fast-to-process functional images.

BioCAM DupleX - the most compact bidirectional platform sending and actuation with 4096 electrodes per well.

When paired with the HD-MEA from the Khíron family (Accura HD-MEA), the BioCAM DupleX can use any of the recording sites to release an electrical stimulus, thus making it a fully bidirectional platform.

Sensing and actuation with 4,096 electrodes

Bidirectional platform

When paired with the HD-MEA from the Khíron family (Accura HD-MEA), the BioCAM DupleX can use any of the recording sites to release an electrical stimulus, thus making it a fully bidirectional platform.
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Coupled with BrainWave, our unique integrated software for recording, stimulation and real-time processing, BioCAM DupleX is the perfect solution for easily setting up complex experiments. Study functional connectivity, information processing or complex behaviors like learning and memory in neuronal networks – all without the need for external stimulating electrodes or third-party electronics.

Sensing and actuation with 4,096 electrodes

Bidirectional platform

When paired with Khíron MEA probes, the BioCAM DupleX can use any of the recording sites to release an electrical stimulation, thus making it a fully bidirectional platform.
‍
Coupled with BrainWave, a unique integrated software for recording/stimulation and real-time processing, BioCAM DupleX allows researchers to easily setup complex experiments to study functional connectivity, information processing and complex behaviors like learning or memory in neuronal networks - all without the need for external stimulating electrodes and third-party electronics.

After inserting a microelectrode array (HD-MEA) chip into the BioCAM DupleX, the motorized locking mechanism activates with a simple press of the lock button to enable precise contact and alignment. The system automatically recognizes the MEA chip and is ready to acquire data.

Touch button and LED interface

Precision at your fingertips

After inserting a microelectrode array (HD-MEA) chip into the BioCAM DupleX, the motorized locking mechanism activates with a simple press of the lock button to enable precise contact and alignment. The system automatically recognizes the MEA chip and is ready to acquire data.

BioCAM Duplex - LED and touch button interface

A convenient set of LED lights shows when the BioCAM DupleX is powered on, whether the MEA chip is locked in and when the system is recording.

The BioCAM DupleX features an integrated reference electrode for the microelectrode array (MEA) chip to simplify the experimental procedure, reducing the risk of contamination, interference noise and accidental spills of media.

A close-up view

Integrated reference

The BioCAM DupleX features an integrated reference electrode for the microelectrode array (MEA) chip to simplify the experimental procedure, reducing the risk of contamination, interference noise and accidental spills of media.

Under the case

Hover on the BioCAM DupleX to discover more.

REAL-TIME PROCESSING

Advanced FPGA control to denoise, filter and compress high-density data

MAGNETIC SURFACES

All surfaces around the MEA chip are magnetic for easy setup with other equipment, such as perfusion holders

TEMPERATURE CONTROL

Integrated heating and cooling system

Magnetic Surface - All the surfaces around the MEA chip are magnetic for easy setup with other equipment, such as perfusion holders

Real time processing - Advanced FPGA control to denoise, filter and compress high-density data.

Integrated Stimulator - 4 independently programmable current stimulator channels

Fast locking system - A motorized solution to reliably lock and unlock your microelectrode array (MEA) chips

BioCAM DupleX - discover more of all the features within this compact microelectrode array device

INTEGRATED STIMULATOR

4 independently programmable current stimulator channels

FAST LOCKING SYSTEM

A motorized solution to reliably lockand unlock microelectrode array (MEA) chips

ROBUST EXTERNAL CASE

Crafted from aluminum to shield from electromagnetic and mechanical interference

REAL-TIME PROCESSING

Advanced FPGA control to denoise, filter and compress high-density data

MAGNETIC SURFACES

All the surfaces around the MEA chip are magnetic for easy setup with other equipment, such as perfusion holders

TEMPERATURE CONTROL

Integrated heating and cooling system

INTEGRATED STIMULATOR

4 independently programmable current stimulator channels

FAST LOCKING SYSTEM

A motorized solution to reliably lock and unlock your microelectrode array (MEA) chips

ROBUST EXTERNAL CASE

Crafted from aluminium to shield from electromagnetic and mechanical noise

Perfect fit in any setup

Compact design for maximum impact

The BioCAM DupleX high-resolution microelectrode array (HD-MEA) platform is packed with features to enrich your research. At the same time, its small footprint makes for easy integration with instruments like microscope and perfusion or patch-clamp systems.
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W 230 mm/9.5''
D 180 mm/7.08''
H 42 mm/1.65''

Perfect fit in any setup

Compact design for maximum impact

The BioCAM DupleX microelectrode array, also known as a multielectrode array (MEA), platform is packed with features to enrich your research. At the same time, its small footprint makes for easy integration with instruments like microscope and perfusion or patch-clamp systems.

W 230mm/9.5''
D 180mm/7.08''
H 39mm/1.53''

Tech specs

Main Controller

Computational core

Intel®'s Arria® 10 FPGA 13Gbps, 2GB DDR4,
and ARM® dual-core Cortex™-A9 1.5 GHz

Data resolution

12 bit

Number of simultaneous recording channels

4096

Sampling frequency (full-array)

20 kHz/electrode

Region-of-interest

1 - 4 independent subsets of electrodes (up to 64kHz sampling frequency)

Temperature control

Active heating and cooling system

Data interface

USB 3.1 Type-C

Ground reference

On-chip integrated

HD-MEA compatibility

Prime, Arena, Stimulo, Accura

3D HD-MEA compatibility

Accura 3D (firmware upgrade required)

Control software compatibility

BrainWave 4 or higher

Inputs

Two analog inputs (-3.3 V to 3.3 V) or triggers (LV-TTL)

Stimulation Module

Integrated current stimulator

Yes

Real-time stimulation controller

Yes

Number of independent channels

3 (2 int. and 1 ext.)

Internal (on-chip) stimulation sites

4,096 (only with HD-MEA Accura)

External stimulation sites

2 (accessible with optional connector box)

Maximum amplitude

+/- 1 mA

Amplitude resolution

10 µA

Time resolution

10 µs

Physical specs

Body material

Anodized aluminum and stainless steel

Locking mechanism

Motorized

Protection from liquid spill over

Anti spill barrier v. 2

Dimensions
(W x D x H)

180 x 230 x 42 mm / 7.09 x 9.05 x 1.65 inches

Weight

2 Kg / 4.4 pounds

Where the functional screening revolution begins

Introducing a fully bi-directional microelectrode array platform for 2D and 3D in vitro imaging

Overview

In vitro electrophysiology reimagined

Our journey to perfection

1 product, 15 years of R&D

Electrophysiology in 3D

An ideal match: BioCAM DupleX and Khíron

Electrophysiology in 3D

An ideal match: BioCAM DupleX and Khíron

Electrophysiology revolutionized

Sensing and actuation with 4,096 electrodes

Bidirectional platform

Sensing and actuation with 4,096 electrodes

Bidirectional platform

Touch button and LED interface

Precision at your fingertips

A close-up view

Integrated reference

Under the case

REAL-TIME PROCESSING

MAGNETIC SURFACES

TEMPERATURE CONTROL

INTEGRATED STIMULATOR

FAST LOCKING SYSTEM

ROBUST EXTERNAL CASE

REAL-TIME PROCESSING

MAGNETIC SURFACES

TEMPERATURE CONTROL

INTEGRATED STIMULATOR

FAST LOCKING SYSTEM

ROBUST EXTERNAL CASE

Perfect fit in any setup

Compact design for maximum impact

Perfect fit in any setup

Compact design for maximum impact

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Stimulation Module

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