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The 6-well CorePlate™-powered microelectrode array platform designed for both cell culture and tissue preparations
Thanks to the CorePlate™ technology, HyperCAM Alpha delivers high resolution functional screening in a multiwell format.
The controlled environment allows label-free in vitro assays over long time periods. The large sensing area of the per-well integrated microchip provides room for measuring either cell cultures, brain slices or brain organoids.
Alpha is equipped with the latest generation of FPGA accelerators to manage real-time high-resolution data from up to 13824 (2304 per well) simultaneously recorded electrodes.
Complex operations are handled by the sophisticated system so you can focus on measuring the functional properties of neurons.
HyperCAM Alpha is a multiwell HD-MEA platform designed to parallel experiments with neuronal cultures, organoids and brain slices. 4096 fully bidirectional electrodes (recording/stimulation) per well allow the real time characterization of neuronal diseases, mutations and effect of drugs at high statistical precision
HyperCAM Alpha is a CorePlate™ powered 6 well platform that handles parallel experiments with neuronal cultures, organoids or brain slices. 4096 fully bidirectional electrodes (recording/stimulating) per well allow real time characterization of neuronal diseases, mutations and cell effectors with a high statistical precision.
The CorePlate™ multiwell is kept under control by accurately monitoring the temperature, CO₂ saturation and humidity of the environment your cells are exposed to. Additionally, the tag functionality of the CorePlate™ technology allows you to easily track your experiments.
HyperCAM Alpha is coupled with the new BrainWave software to visualize and analyze complex network data from your preparation just in a click, providing the new gold standard for neuronal big data management.
HyperCAM Alpha is coupled with the new BrainWave v.5 software to easily visualize and analyze network data from a multiwell configuration. Advanced data processing coupled to a smart user interface brings you one click away from charting any functional change in the network activity.
The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations
Thanks to the CorePlate™ technology, HyperCAM Alpha delivers high resolution functional screening in a multiwell format.
The controlled environment allows label-free kinetic in vitro assays. The large sensing area of the per-well integrated microchip provides room for measuring either cell cultures, brain slices or brain organoids.
Alpha is equipped with the latest generation of FPGA accelerators to manage real-time high-resolution data from up to 13824 (2304 per well) simultaneously recorded electrodes.
Complex operations are handled by the sophisticated system so you can focus on measuring the functional properties of neurons.
Parallelization does not have to be achieved at the cost of sacrificing data quality. Thanks to the 6-well CorePlate™ technology, Alpha provides thousands of electrodes per-well that can be arranged in different recording configurations to satisfy any experimental needs. The high statistical quality of the data generated by each well reduces the overall needs of replicates. While also giving access to single-cell details with a spatio- temporal resolution comparable to that provided by our single well HD-MEAs.
Parallelization does not have to be achieved at the cost of sacrificing data quality. Thanks to the 6-well CorePlate™ technology, Alpha provides thousands of electrodes per-well that can be arranged in different recording configurations to satisfy any experimental needs. The high statistical quality of the data generated by each well reduces the overall needs of replicates. While also giving access to single-cell details with a spatio- temporal resolution comparable to that provided by our single well HD-MEAs.
Regardless of whether you want to record human iPSC-derived neurons, dissociated murine cultures, acute brain and cardiac tissues, complex 3D neuronal assemblies, spheroids or brain organoids, HyperCAM Alpha is always your best choice.
Alpha leaves the freedom to operate with the chamber closed to provide incubator-like conditions for long term recordings as well as in an open configuration for acute measurement requiring the integration of fluidic systems. In both cases, optical access is guaranteed to always keep your preparations under control.
HyperCAM Alpha is designed to reduce experimental hassles and allows you to fully concentrate on the most important thing: your assay.
The CorePlate™ multiwell’s environment is regulated by accurately controlling the temperature, CO₂ saturation and humidity through the software or even the integrated touchscreen.
The incubation chamber is water-proof to protect instrument electronics from accidental spill-out or experimental misuse.
The combination with the latest BrainWave software allows to easily visualize and analyze data from CorePlate™ devices.
Computational core
Intel®’s Arria® 10 FPGA 13Gbps, 2GB DDR4,
and ARM® dual-core Cortex™-A9 1.5 GHz
Data resolution
14 bit
Compatible with
6-well CorePlate™ technology
Number of simultaneous recording channels
13824 (2304 per well) @10kHz
or 6144 (1024 per well) @20kHz
Environmental chamber
With controlled temperature and CO2
concentration (via integrated air mixer)
and with monitored humidity
Touch screen
100k dots to read and set status
environmental chamber values and
perform basic operations
(e.g., read/set temperature and
CO2, read RH%, lock/unlock the
CorePlate™ device, etc.)
Data interface
USB 3.1 Type-C data interface
Control software compatibility
BrainWave 5 or higher
Integrated current stimulator
Yes
Number of independent channels
2
Stimulation sites
24'576 (4'096 per well)
Maximum amplitude
+/- 1 mA
Amplitude resolution
10 µA
Time resolution
10 µs
Body material
Plastic
Chamber lid
Movable lid with transparent window that
can be operated either by the software or
manually
Locking mechanism
Motorized CorePlate™ locking system
Protection from liquid spill over
Chamber protected against dripping water
Dimensions
(W x D x H)
417 x 248 x 154 mm
Weight
8.5 Kg / 18.7 pounds
