3Brain - CorePlate™ Tech

Bringing deep tech to cell culture assays

Simple, elegant, brilliant

Our journey to perfection

CorePlate™ technology is deep tech for cell culture

Traditional plastic plate

Traditional 96 well

Intelligent CorePlate™

3Brain's Intelligent CorePlate™ to allow for real-time capture of all electrophysiological activity at high temporal and spacial resolution.
3Brain's BioSPU chip3Brain's BioSPU chip

BioSPU chip

We developed the CorePlate™ technology to transform standard cell culture dishes into intelligent devices.

Each culture well now integrates a semiconductor processing core, namely a custom-designed silicon BioSPU (BioSignal Processing Unit).

The BioSPU integrates thousands of sensors and actuators in a few square millimeters, with processing speed that perfectly matches the processing power of a cell network to allow for real-time capture of all electrophysiological activity at high temporal and spacial resolution.

We developed the CorePlate™ technology to transform standard cell culture dishes into intelligent devices.

Each culture well now integrates a semiconductor processing core, namely a custom-designed silicon BioSPU (BioSignal Processing Unit).

The BioSPU integrates thousands of sensors and actuators in a few square millimeters, with processing speed that perfectly matches the processing power of a cell network to allow for real-time capture of all electrophysiological activity at high temporal and spacial resolution.

A broadband connection to living organisms

CorePlate™ links cellular networks to software

TRADITIONAL PARADIGM

Limitations of traditional microelectrode arrays

Microscopy-based high content screening approaches face many obstacles such as phototoxicity, photobleaching and dye-mediated modification of cell physiology. They exhibit worse temporal resolution because they rely on sequential measurement, rather than parallel real-time assessment of multiple cells.

Traditional microelectrode arrays or patch-clamp approaches are limited by poor spatial resolution, noise or low throughput.

3BRAIN APPROACH

3Brain's approach for high throughput microelectrode array

CorePlate™ technology brings a processing core in contact with the cell network, delivering a granular picture of the cellular network activity like a high-definition camera. Free of speed or bandwidth constraints, the BioSPU core efficiently pre-processes cell data in-situ at the source with the best-quality output.

No more losing critical data, get an accurate picture of cell network dynamics with a few easy clicks using our machine learning empowered analysis software BrainWave 5.

Advanced big data capture & processing

Investigate network dynamics at unprecedented resolution

Compared to current methodologies, CorePlate™ empowers your screening workflow in multiple ways by several orders of magnitude to yield the best translational outcomes.

Gaining illuminating insights into cellular networks was never easier:

Fast on-chip processing

Real-time measurements, signal amplification and in-situ noise filtering.

Optimized data wrangling

Unparalleled efficiency in data management and storage.

Harnessing A.I.

Create informative & reproducible data that power A.I. to increase translational quality.

Bioengineering for the future

3D - the next frontier in advanced in-vitro models

The in-vitro cell-based assay field is constantly evolving. The rise of human-derived stem cell technology and the progression toward more in vivo-like human models raise new challenges in identifying reliable and efficient readout technologies.
Especially for brain research, network heterogeneity and the topological properties deeply impact connectivity and signal propagation in ways we don't yet understand.

We at 3Brain are committed to ongoing development of innovative products – like the 3D BioSPU – to maximize the potential of the dense information acquired from advanced in-vitro models such as human-derived organoids or spheroids.

3Brain's 3D BioSPU technology

Experience that matters

15 years of progress

Since the early 2000s, we at 3Brain have worked to push the boundaries of CMOS technology applied to cell networks and have become a leader in the field of high-resolution electrophysiological platforms.
As the first company to optimize CMOS technology for electrogenic cells, we have overcome the challenges that have accompanied this novel technology. Our engineers have worked diligently to continue releasing new and improved circuit designs that best fit the needs of researchers working with neuronal and cardiac cells. From generation 0 to generation 3 (Khíron chip) and the next line currently under development, it is our knowledge and years of experience that culminate in better and better CMOS-MEAs.

2004
Idea
GEN 0
2012
2012 3Brain's "Apollo" Generation 1
Apollo
GEN 1
2015
2015 3Brain's "Artemis" Generation 2
Artemis
GEN 2
2019
Khíron
2021
Khíron v.2
GEN 3
2004
2004 3Brain's "Idea" Generation 0
Idea
GEN 0
2012
2012 3Brain's "Apollo" Generation 1
Apollo
GEN 1
2015
2015 3Brain's "Artemis" Generation 2
Artemis
GEN 2
2019 3Brain's "Khíron" Generation 3
2019
Khíron
2021
Khíron v2
GEN 3
2004
2012
2015
2019
2021
2012 3Brain's "Apollo" Generation 12015 3Brain's "Artemis" Generation 2
Idea
Apollo
Artemis
Khíron
Khíron v.2
GEN 0

GEN 1

GEN 2

GEN 3
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